Kate S. Arbon
College of Idaho
2 Papers
35 Citations
Kate S. Arbon is an academic researcher from College of Idaho. The author has contributed to research in topics: Apoptosis & Osteoblast. The author has an hindex of 2, co-authored 2 publications.
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Papers
Cadmium-induced decrease in RUNX2 mRNA expression and recovery by the antioxidant N-acetylcysteine (NAC) in the human osteoblast-like cell line, Saos-2.
Spenser S. Smith,Jackeline Rodriguez Reyes,Kate S. Arbon,Wendy A. Harvey,Lindsey M. Hunt,Sara J. Heggland +5 more
TL;DR: It is hypothesized that cadmium exposure induces oxidative stress which leads to decreased RUNX2 mRNA expression and increased apoptotic death, and predicted that the antioxidant NAC mitigates the damaging effects of cadmiam.
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Cadmium exposure activates the ERK signaling pathway leading to altered osteoblast gene expression and apoptotic death in Saos-2 cells.
TL;DR: Cadmium can directly inhibit osteoblasts via ERK signaling pathway and identifies SOST as a target for cadmium-induced osteotoxicity, as well as examine the extracellular signal-regulated protein kinase (ERK) andprotein kinase C (PKC) pathways in cadmity-induced apoptosis and altered osteoblast gene expression.
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