Kate Powell
UCL Institute of Ophthalmology
5 Papers
4 Citations
Kate Powell is an academic researcher from UCL Institute of Ophthalmology. The author has contributed to research in topics: Mutation (genetic algorithm) & Retinal degeneration. The author has an hindex of 3, co-authored 5 publications.
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Papers
Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179
Koji Nishiguchi,Livia S. Carvalho,Matteo Rizzi,Kate Powell,Sophia-Martha Kleine Holthaus,Selina A. Azam,Yanai Duran,Joana Ribeiro,Ulrich F O Luhmann,James W B Bainbridge,Alexander J. Smith,Robin R. Ali +11 more
TL;DR: Gene replacement in rd1 mice that are devoid of the mutation in Gpr179 successfully restores the function of both photoreceptors and bipolar cells, which is maintained for up to 13 months.
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Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors
Joana Ribeiro,Christopher A. Procyk,Emma L. West,Michelle O’Hara-Wright,Monica F. Martins,Majid Moshtagh Khorasani,Aura Hare,Mark Basche,Milan Fernando,Debbie Goh,Neeraj Jumbo,Matteo Rizzi,Kate Powell,Menahil Tariq,Michel Michaelides,James W B Bainbridge,Alexander J. Smith,Rachael A. Pearson,Anai Gonzalez-Cordero,Robin R. Ali,Robin R. Ali +20 more
TL;DR: In this paper, human pluripotent stem cell-derived cones were transplanted into a mouse model of advanced macular degeneration to restore light-sensing cone photoreceptors.
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Do Visual Circuits Mature Without Visual Stimuli
TL;DR: The mammalian neocortex is intricately and nonrandomly wired, and Sophisticated neocortical circuits are essential for the emergence of complex brain functions.
3
Targeting lateral inhibition to improve vision following macular degeneration
Matteo Rizzi,Kate Powell,Robinson,Takaaki Matsuki,Justin Hoke,Ryea Maswood,Anastasios Georgiadis,Michalis Georgiou,Pete R. Jones,Caterina Ripamonti,Michel Michaelides,Gary S. Rubin,Alexander J. Smith,Robin R. Ali +13 more
TL;DR: It is found that loss of lateral inhibition as a specific mechanism by which photoreceptor degeneration reduces visual function beyond the atrophic area is adaptive, and that if modulated can improve visual function, making inhibitory circuits an unexpected therapeutic target for age related macular degeneration and related disorders.