Kate E. Unsworth

TL;DR: It is shown that, several hours after bacterial uptake into different host cell types, Salmonella induces the formation of an F‐actin meshwork around bacterial vacuoles, which plays an important role in the establishment of an intracellular niche that sustains bacterial growth.

TL;DR: Results show that SpiC is involved in the process of SPI‐2 secretion and indicate that phenotypes associated with a spiC‐ mutant are caused by the inability of this strain to translocate effector proteins, thus calling for further investigation into the function(s) of this protein.

TL;DR: The results suggest that mutation of phoP may compensate partially for defects in the SPI-2 T TSS by deregulating SPI-1 TTSS expression, and provide an explanation for previous reports showing an apparent functional overlap between these two systems in vitro.

TL;DR: Signature-tagged mutagenesis is a mutation-based screening method for the identification of virulence genes of microbial pathogens as mentioned in this paper. Genes isolated by this approach fall into three classes: those with known biochemical function, those of suspected function and some whose functions cannot be predicted from database searches.