Katashi Deguchi
Kyoto University
9 Papers
9 Citations
Katashi Deguchi is an academic researcher from Kyoto University. The author has contributed to research in topics: MDA5 & RNA. The author has an hindex of 5, co-authored 9 publications.
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Papers
Autoimmune disorders associated with gain of function of the intracellular sensor MDA5.
Masahide Funabiki,Hiroki Kato,Yoshiki Miyachi,Hideaki Toki,Hiromi Motegi,Maki Inoue,Osamu Minowa,Aiko Yoshida,Katashi Deguchi,Hiroshi Sato,Sadayoshi Ito,Toshihiko Shiroishi,Kunio Takeyasu,Tetsuo Noda,Takashi Fujita +14 more
TL;DR: Direct evidence that dysregulation of MDA5 caused autoimmune disorders is provided and insight is provided into the association between disorders of the innate immune system and autoimmunity.
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Viral RNA recognition by LGP2 and MDA5, and activation of signaling through step-by-step conformational changes
Ivana Duic,Hisashi Tadakuma,Hisashi Tadakuma,Yoshie Harada,Ryo Yamaue,Katashi Deguchi,Yuki Suzuki,Shige H. Yoshimura,Hiroki Kato,Hiroki Kato,Kunio Takeyasu,Takashi Fujita,Takashi Fujita +12 more
TL;DR: A mechanistic basis for LGP2-mediated regulation of MDA5 antiviral innate immune responses is revealed and coordinated actions of L GP2 and MDA3 are demonstrated, where LGP1 acts as an MDA4 nucleator and requisite partner in the conversion of Mda5 to an active conformation.
Probing in vivo dynamics of mitochondria and cortical actin networks using high-speed atomic force/fluorescence microscopy.
Aiko Yoshida,Nobuaki Sakai,Yoshitsugu Uekusa,Katashi Deguchi,Jamie L. Gilmore,Masahiro Kumeta,Shuichi Ito,Kunio Takeyasu +7 more
TL;DR: A combined atomic force/optical microscope system is used to analyze membrane‐based cellular events at nanometer‐scale resolution in live cells to provide novel insights into the structural aspects of the entire cell membrane machinery which can be visualized with high temporal and spatial resolution.
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Analyses of nuclear proteins and nucleic acid structures using atomic force microscopy.
Jamie L. Gilmore,Aiko Yoshida,Hirohide Takahashi,Katashi Deguchi,Toshiro Kobori,Emilie Louvet,Masahiro Kumeta,Shige H. Yoshimura,Kunio Takeyasu +8 more
TL;DR: A variety of methods for studying nuclear samples including single nucleic acid molecules, higher-order chromatin structures, the nucleolus, and the nucleus are described, as well as protocols describing how to prepare the AFM substrate and theAFM tip.
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Structural Analysis of Long Single-Stranded RNA Molecules with Atomic Force Microscopy Imaging
Jamie L. Gilmore,Aiko Yoshida,Katashi Deguchi,Suguru Asai,Hideki Aizaki,Masahiro Kumeta,Kiwamu Hyodo,Tetsuro Okuno,Takaji Wakita,Kunio Takeyasu +9 more
- 01 Jan 2017
TL;DR: This study has developed an imaging procedure for obtaining images of the extended secondary structures of long RNA molecules combined with automated MATLAB-based data processing algorithms for identification of the domain architecture of the molecules in these images.
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