Katarzyna Tilgner
Newcastle University
16 Papers
30 Citations
Katarzyna Tilgner is an academic researcher from Newcastle University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 12, co-authored 14 publications. Previous affiliations of Katarzyna Tilgner include Centre for Life & Wellcome Trust.
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Papers
Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells.
Lyle Armstrong,Katarzyna Tilgner,Gabriele Saretzki,Stuart P. Atkinson,Miodrag Stojkovic,Rubén Moreno,Stefan Przyborski,Majilinda Lako +7 more
TL;DR: Together the data suggest that, during the reprogramming process, certain cellular mechanisms are in place to ensure that hiPSC are provided with the same defense mechanisms against accumulation of ROS as the hESC.
300
An Induced Pluripotent Stem Cell Model of Hypoplastic Left Heart Syndrome (HLHS) Reveals Multiple Expression and Functional Differences in HLHS-Derived Cardiac Myocytes
Yan Jiang,Saba Habibollah,Katarzyna Tilgner,Joseph Collin,Tomáš Bárta,Jumana Y. Al-Aama,Lenka Tesarov,Rafiqul Hussain,Andrew W. Trafford,Graham Kirkwood,Evelyne Sernagor,Cyril G. Eleftheriou,Stefan Przyborski,Miodrag Stojkovic,Majlinda Lako,Bernard Keavney,Lyle Armstrong +16 more
TL;DR: CMs derived from an HLHS patient demonstrate a number of marker expression and functional differences to hESC/control iPSC‐derived CMs, thus providing some evidence that cardiomyocyte‐specific factors may influence the risk of HLHS.
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Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease.
Yan Jiang,Sally A. Cowley,Ulrich Siler,Dario Melguizo,Katarzyna Tilgner,Cathy Browne,Angus Dewilton,Stefan Przyborski,Gabriele Saretzki,William James,Reinhard Seger,Janine Reichenbach,Majlinda Lako,Lyle Armstrong +13 more
TL;DR: Results suggest that CGD‐patient‐specific iPSC lines represent an important tool for modeling CGD disease phenotypes, screening candidate drugs, and the development of gene therapy.
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Brief Report: Human Pluripotent Stem Cell Models of Fanconi Anemia Deficiency Reveal an Important Role for Fanconi Anemia Proteins in Cellular Reprogramming and Survival of Hematopoietic Progenitors
Sun Yung,Katarzyna Tilgner,Maria H. Ledran,Saba Habibollah,Irina Neganova,Chatchawan Singhapol,Gabriele Saretzki,Miodrag Stojkovic,Lyle Armstrong,Stefan Przyborski,Majlinda Lako +10 more
TL;DR: It is reported that FA‐C patient‐specific hiPSC lines can be derived under normoxic conditions, albeit at much reduced efficiency, and these data highlight the critical requirement for FA proteins in survival of hematopoietic progenitors, cellular reprogramming, and maintenance of genomic stability.
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iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.
Dario Melguizo-Sanchis,Yaobo Xu,Dheraj Taheem,Min Yu,Katarzyna Tilgner,Tomáš Bárta,Katja Gassner,George Anyfantis,Tengfei Wan,Ramu Elango,Sameer E. Al-Harthi,Ashraf A. El-Harouni,Stefan Przyborski,Soheir S. Adam,Soheir S. Adam,Gabriele Saretzki,Sujith Samarasinghe,Lyle Armstrong,Majlinda Lako +18 more
TL;DR: In this paper, the authors derived induced pluripotent stem cells (iPSC) from three unaffected controls and three severe aplastic anemia (SAA) patients and have shown that this in vitro model mimics two key features of the disease: (1) the failure to maintain telomere length during the reprogramming process and hematopoietic differentiation resulting in SAA-iPSCs and iPSC-derived progenitors with shorter telomeres than controls.