Karrie E. Wheatley
University of Texas at Austin
4 Papers
71 Citations
Karrie E. Wheatley is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Calorie restriction & White adipose tissue. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Karrie E. Wheatley include University of Texas MD Anderson Cancer Center.
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Papers
Differential Effects of Calorie Restriction and Exercise on the Adipose Transcriptome in Diet-Induced Obese Mice
Karrie E. Wheatley,Leticia Nogueira,Leticia Nogueira,Leticia Nogueira,Susan N. Perkins,Stephen D. Hursting,Stephen D. Hursting +6 more
TL;DR: Chromatin immunoprecipitation assays of the Glut4 promoter revealed that, relative to the DIO controls, CR significantly increased histone 4 acetylation, suggesting epigenetic regulation may underlie some of the differential effects of CR versus EX on the adipose transcriptome.
The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001
Rebecca E. De Angel,Claudio J. Conti,Karrie E. Wheatley,Karrie E. Wheatley,Andrew Brenner,Glen Otto,Linda A. deGraffenried,Linda A. deGraffenried,Stephen D. Hursting,Stephen D. Hursting +9 more
TL;DR: It is suggested that combination of lifestyle and pharmacologic strategies may be effective for breaking the obesity–breast cancer link, and weight normalization in obese mice does not immediately reverse tumor progression or Akt/mTOR activation.
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Low-carbohydrate diet versus caloric restriction: effects on weight loss, hormones, and colon tumor growth in obese mice.
Karrie E. Wheatley,Elizabeth A. Williams,Nicole C P Smith,Alice C. Dillard,Eun Young Park,Nomeli P. Nunez,Stephen D. Hursting,Michelle Lane +7 more
TL;DR: The data suggest LC diets do not slow colon tumor growth in obese mice, and IGF-I levels were lower in the LC group than the HF group, but tumor growth did not differ.
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Obesity, independent of p53 gene dosage, promotes mammary tumor progression and upregulates the p53 regulator microRNA-504.
TL;DR: The findings in murine models of postmenopausal breast cancer suggest that obesity may augment procancer effects related to p53 gene alterations, and microRNA-504, an obesity-responsive negative regulator of p53 and putative EMT regulator, may represent a novel molecular target for breaking the obesity-breast cancer link.