Karolin Pohle
Technische Universität München
15 Papers
204 Citations
Karolin Pohle is an academic researcher from Technische Universität München. The author has contributed to research in topics: Chemistry & Integrin. The author has an hindex of 10, co-authored 15 publications. Previous affiliations of Karolin Pohle include University of Jena.
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Papers
Comparative gallium-68 labeling of TRAP-, NOTA-, and DOTA-peptides: practical consequences for the future of gallium-68-PET.
TL;DR: High 68Ga labeling efficiency of TRAP-peptides could facilitate realization of kit labeling procedures and the possibility to provide very high specific activities offers a high degree of safety in first clinical trials, due to reduction of cold mass content in tracer formulations.
Be spoilt for choice with radiolabelled RGD peptides: preclinical evaluation of ⁶⁸Ga-TRAP(RGD)₃.
TL;DR: It is concluded that ⁶⁸Ga-TRAP(RGD)₃ could allow for imaging of low-level integrin expression in tissues which are not visible with the two competitors, and constitutes proof of concept for the favourable in vivo properties of TRAP-based ₸Ga radiopharmaceuticals.
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with high specific activity in a cGMP/GRP compliant automated process
Karolin Pohle,Johannes Notni,Johanna Bussemer,Horst Kessler,Markus Schwaiger,Ambros J. Beer +5 more
- 01 Jan 2012
TL;DR: In this article, a comparison of the pharmacokinetic properties of NODAGA-cyclo(RGDyK) tracer with 18 F-Galacto-Cyclo-RGDfK tracer is presented.
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Selective Imaging of the Angiogenic Relevant Integrins α5β1 and αvβ3
Stefanie Neubauer,Florian Rechenmacher,Ambros J. Beer,Flavio Curnis,Karolin Pohle,Calogero D'Alessandria,Hans-Jürgen Wester,Ute Reuning,Angelo Corti,Markus Schwaiger,Horst Kessler,Horst Kessler +11 more
TL;DR: The first α5β1-selective integrin antagonist that enables specific molecular imaging by positron emission tomography was developed and could target and discriminate between tumor cells in’vivo based on their different integrin patterns and also delay tumor growth in vivo.
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Multimodal Molecular Imaging of Integrin αvβ3 for In Vivo Detection of Pancreatic Cancer
Marija Trajkovic-Arsic,Pouyan Mohajerani,Athanasios Sarantopoulos,E Kalideris,Katja Steiger,Irene Esposito,Xiaopeng Ma,George Themelis,Neal C. Burton,Christoph W. Michalski,Jörg Kleeff,Stefan Stangl,Ambros J. Beer,Karolin Pohle,Hans-Jürgen Wester,Roland M. Schmid,Rickmer Braren,Vasilis Ntziachristos,Jens T. Siveke +18 more
TL;DR: Imaging approaches targeting αvβ3 integrin expand the potential of molecular imaging for identification of αv β3-positive PDAC with potential implications in early detection, fluorescence-guided surgery, and therapy monitoring.
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