Publisher Summary This chapter discusses protein metabolism and requirements in pregnancy and lactation. During pregnancy and more especially during lactation, the net rate of protein synthesis by the adult mammal is greatly increased. Lactation implies a rate of synthesis of new protein that is three-to tenfold that noted in pregnancy. However, the rate of synthesis per kilogram of body weight in all species is less in lactation than in early life. The apparent exception of man is largely because of the inclusion of a large term for augmentation of the N content of the tissues of the mother during pregnancy. If the synthesis of pregnancy in women is taken to be the protein deposited in the uterus plus that contributing to the growth of the breast, then the net rate of synthesis is reduced to a third. Net rates of protein synthesis vary appreciably from species to species and on average, the rat synthesizes about 10 times as much protein per unit time per unit body weight as does man, irrespective of whether it is growing, pregnant, or lactating.

Protein Metabolism and Requirements in Pregnancy and Lactation

Publisher Summary This chapter focuses on the concept of protein synthesis, with special reference to growth processes, both normal and abnormal. The chapter reviews the known facts concerning protein synthesis. Much is now known about the structure of proteins and the ways in which protein synthesis may be followed; both aspects of the subject, which are essential, preliminaries to an understanding of the way in which proteins are synthesized. Both in carbohydrate metabolism and fat metabolism, the most rapid advances had to await the development of methods involving cell-free systems. This knowledge has acted as an incentive to develop similar methods for the study of protein synthesis, but so far it has not been possible to demonstrate the synthesis of a specific protein in a cell-free system. It seems more likely that many subcellular components play a part in the synthesis of a complete protein. The isolation of such components and the understanding of their function require the close collaboration of the electron microscopist and the biochemist.

Protein synthesis with special reference to growth processes both normal and abnormal.

Studien zur entwicklungsphysiologie des protein-stoffwechsels in verschiedenen organen des kaninchens☆

Bei hoheren Lebewesen lassen sich Lebensphasen (Jugend, Reife, Alter, Tod) abgrenzen, welche sich in bezug auf die Aktivitat des Eiweisstoffwechsels unterscheiden. Die Ausbildung von Organen setzt die Determinierung von Zellen und Zellverbanden zu Einheiten mit gemeinsamer Struktur und spezifischen Leistungen voraus. Diese Differenzierungsvorgange sind in ihrem morphologischen Ablauf gut studiert.

Eiweißsynthese in der Prä- und Postnatalperiode

Über den Einbau von 2-14C-Glykokoll in die Nucleinsäuren und Proteine der fötalen und mütterlichen Gewebe bei der Ratte

Über das Verhalten der Nucleinsäuren in Leber, Muskulatur und Gehirn während der Fötalentwicklung von Ratten

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Über den Einbau von 2-14C-Glykokoll in die Nucleinsäuren und Proteine der fötalen und mütterlichen Gewebe bei der Ratte

Über das Verhalten der Nucleinsäuren in Leber, Muskulatur und Gehirn während der Fötalentwicklung von Ratten