Karine Bigot
Vision Institute
4 Papers
6 Citations
Karine Bigot is an academic researcher from Vision Institute. The author has contributed to research in topics: Action spectrum & Oxidative stress. The author has an hindex of 3, co-authored 4 publications. Previous affiliations of Karine Bigot include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Papers
Phototoxic action spectrum on a retinal pigment epithelium model of age-related macular degeneration exposed to sunlight normalized conditions.
Emilie Arnault,Emilie Arnault,Emilie Arnault,Coralie Barrau,Céline Nanteau,Céline Nanteau,Céline Nanteau,Pauline Gondouin,Pauline Gondouin,Pauline Gondouin,Karine Bigot,Karine Bigot,Karine Bigot,Françoise Viénot,Emmanuel Gutman,Emmanuel Gutman,Emmanuel Gutman,Valérie Fontaine,Valérie Fontaine,Valérie Fontaine,Thierry Villette,Denis Cohen-Tannoudji,José-Alain Sahel,Serge Picaud +23 more
TL;DR: Surprisingly, a narrow bandwidth in blue light generated the greatest phototoxic risk to retinal pigment epithelium cells, and may be advantageously valued in designing selective photoprotection ophthalmic filters, without disrupting essential visual and non-visual functions of the eye.
Light action spectrum on oxidative stress and mitochondrial damage in A2E-loaded retinal pigment epithelium cells
Melanie Marie,Karine Bigot,Claire Angebault,Coralie Barrau,Pauline Gondouin,Delphine Pagan,Stéphane Fouquet,Thierry Villette,José-Alain Sahel,Guy Lenaers,Serge Picaud +10 more
TL;DR: In this paper, the authors used a custom-made illumination device that delivers 10nm-wide light bands under the blue-green part of the solar spectrum that reaches the retina to better understand the mechanisms underlying light-elicited toxicity.
Blue light toxic action spectrum on A2E-loaded RPE cells in sunlight normalized conditions
TL;DR: The precise spectrum of light toxicity in physiological irradiance conditions on an in vitro model of AMD is described for the first time, providing new information for designing selective protective filters, without disrupting visual and non-visual functions.
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