Karina Balan
Wayne State University
8 Papers
Karina Balan is an academic researcher from Wayne State University. The author has contributed to research in topics: Biology & MAP kinase kinase kinase. The author has an hindex of 8, co-authored 8 publications. Previous affiliations of Karina Balan include Texas A&M University.
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Papers
p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.
Brandon M. Hall,Vitaly Balan,Anatoli S. Gleiberman,Evguenia Strom,Peter Krasnov,Lauren P. Virtuoso,Elena Rydkina,Slavoljub Vujcic,Karina Balan,Ilya Gitlin,Katerina I. Leonova,Camila Rosat Consiglio,Sandra O. Gollnick,Olga B. Chernova,Andrei V. Gudkov +14 more
- 02 Aug 2017
TL;DR: It is reported that expression of p 16Ink4a and SAβG in macrophages is acquired as part of a physiological response to immune stimuli rather than through senescence, consistent with reports that p16InK4a plays a role in Macrophage polarization and response.
Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells
Brandon M. Hall,Vitaly Balan,Anatoli S. Gleiberman,Evguenia Strom,Peter Krasnov,Lauren P. Virtuoso,Elena Rydkina,Slavoljub Vujcic,Karina Balan,Ilya Gitlin,Katerina I. Leonova,Alexander Polinsky,Olga B. Chernova,Andrei V. Gudkov +13 more
- 06 Jul 2016
TL;DR: Old mice with elevated proportion of p16(Ink4a)/β-galpH6-positive cells in their tissues demonstrated reduction of both following systemic clodronate treatment, indicating that a significant proportion of cells previously considered to be SCs are actually a subclass of macrophages.
Identification of Novel In Vivo Raf-1 Phosphorylation Sites Mediating Positive Feedback Raf-1 Regulation by Extracellular Signal-regulated Kinase
Vitaly Balan,Deborah T. Leicht,Jun Zhu,Karina Balan,Alexander Kaplun,Vinita Singh-Gupta,Jun Qin,Hong Ruan,Michael J. Comb,Guri Tzivion +9 more
TL;DR: This study describes the identification of new in vivo Raf-1 phosphorylation sites targeted by ERK and provides a novel mechanism for a positive feedback Raf-2 regulation, and its phosphopeptide composition is similar to that of the general Raf- 1 population.
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Identification of Raf-1 S471 as a Novel Phosphorylation Site Critical for Raf-1 and B-Raf Kinase Activities and for MEK Binding
Jun Zhu,Vitaly Balan,Vitaly Balan,Agnieszka Bronisz,Karina Balan,Karina Balan,Hengrui Sun,Deborah T. Leicht,Zhijun Luo,Jun Qin,Joseph Avruch,Guri Tzivion,Guri Tzivion +12 more
TL;DR: It is shown that Raf-1 dephosphorylation, primarily at epidermal growth factor (EGF)-induced sites, abolishes Raf-2 kinase activity and points to the possibility that the V599E mutation activates B-Raf by mimicking a phosphorylation at the S578 site.
Proteomic analysis of human epileptic neocortex predicts vascular and glial changes in epileptic regions
TL;DR: This study is unique in that for each of these six patients the comparison of protein expression was made within the same patient: a more epileptic region was compared to a less epileptic brain region, which provides new insights into the structural and functional basis of neocortical epilepsy.