Karin J. von Eije
University of Amsterdam
14 Papers
60 Citations
Karin J. von Eije is an academic researcher from University of Amsterdam. The author has contributed to research in topics: RNA interference & Small hairpin RNA. The author has an hindex of 9, co-authored 12 publications.
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Papers
Lentiviral Vector Design for Multiple shRNA Expression and Durable HIV-1 Inhibition
Olivier ter Brake,Karen 't Hooft,Ying Poi Liu,Mireille Centlivre,Karin J. von Eije,Ben Berkhout +5 more
TL;DR: Whereas HIV-1 could escape from a single shRNA, it is shown that HIV- 1 escape can be prevented when four shRNAs are simultaneously expressed in a cell.
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Global disparities in SARS-CoV-2 genomic surveillance
Anderson F. Brito,Elizaveta Semenova,Gytis Dudas,Gabriel Hassler,Chaney C. Kalinich,Moritz U. G. Kraemer,Joses Ho,Houriiyah Tegally,George Githinji,Charles N. Agoti,Lucy E Matkin,Charles Whittaker,Benjamin P Howden,Vitali Sintchenko,Neta S. Zuckerman,Orna Mor,Heather M. Blankenship,Tulio de Oliveira,Raymond T. P. Lin,Marilda M. Siqueira,Paola Cristina Resende,Ana Tereza Ribeiro de Vasconcelos,Fernando Rosado Spilki,Renato S. Aguiar,Ivailo Alexiev,Ivan Ivanov,Ivva Philipova,Christine V.F. Carrington,Nikita Sahadeo,Ben Branda,Cèline Gurry,Sebastian Maurer-Stroh,Dhamari Naidoo,Karin J. von Eije,Mark D. Perkins,Maria D. Van Kerkhove,Sarah C. Hill,Ester Cerdeira Sabino,Oliver G. Pybus,C. Dye,Samir Bhatt,Seth Flaxman,Marc A. Suchard,Nathan D. Grubaugh,Guy Baele,Nuno R. Faria +45 more
TL;DR: In this paper , the authors investigated the global SARS-CoV-2 genomic surveillance, using sequences shared via GISAID to estimate the impact of sequencing intensity and turnaround times on variant detection in 189 countries.
Combinatorial RNAi Against HIV-1 Using Extended Short Hairpin RNAs
Ying Poi Liu,Karin J. von Eije,Nick C.T. Schopman,Jan-Tinus Westerink,Olivier ter Brake,Joost Haasnoot,Ben Berkhout +6 more
TL;DR: E-shRNAs can be used as a combinatorial RNAi approach to target error-prone viruses and it is shown that HIV-1 replication is durably inhibited in T cells stably transduced with a lentiviral vector containing the e3-shRNA expression cassette.
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Zika virus and the risk of imported infection in returned travelers: Implications for clinical care.
Abraham Goorhuis,Karin J. von Eije,R. A. Douma,N Rijnberg,Michèle van Vugt,Cornelis Stijnis,Martin P. Grobusch +6 more
TL;DR: Five cases of imported Zika virus infection to The Netherlands are reported, establishing the diagnosis is important, mainly because of the association with congenital microcephaly and the possibility of sexual transmission.
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Disturbance of the microRNA pathway by commonly used lentiviral shRNA libraries limits the application for screening host factors involved in hepatitis C virus infection
Qiuwei Pan,Petra E. de Ruiter,Karin J. von Eije,Ron Smits,Jaap Kwekkeboom,Hugo W. Tilanus,Ben Berkhout,Harry L.A. Janssen,Luc J. W. van der Laan +8 more
TL;DR: It was found that these shRNA library vectors caused non‐specific disturbance of HCV replication that was not due to toxicity or interferon response, but related to the high shRNA levels disturbing the endogenous microRNA biogenesis.
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