Karin Fink
Université de Montréal
9 Papers
Karin Fink is an academic researcher from Université de Montréal. The author has contributed to research in topics: Innate immune system & Regulation of gene expression. The author has an hindex of 9, co-authored 9 publications. Previous affiliations of Karin Fink include French Institute of Health and Medical Research.
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Papers
Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression.
Anton Soucy-Faulkner,Espérance Mukawera,Karin Fink,Alexis Martel,Loubna Jouan,Yves Nzengue,Daniel Lamarre,Christine Vande Velde,Nathalie Grandvaux +8 more
TL;DR: It is found that NOX2 and ROS are required for the host cell to trigger an efficient RIG-I-mediated IRF-3 activation and downstream antiviral IFNβ and IFIT1 gene expression and evidence that NOx2 is critical for the expression of the central mitochondria-associated adaptor MAVS is provided.
STAT2 and IRF9: Beyond ISGF3.
Karin Fink,Nathalie Grandvaux +1 more
- 18 Dec 2013
TL;DR: Current knowledge of the stimuli, regulatory mechanisms, and function of the alternative STAT1-independent complexes/pathways that are thought to trigger different transcriptional programs are summarized.
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Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses.
Martin Baril,Salwa Es-Saad,Laurent Chatel-Chaix,Karin Fink,Tram N. Q. Pham,Valérie-Ann Raymond,Karine Audette,Anne-Sophie Guenier,Jean Duchaine,Marc J. Servant,Marc Bilodeau,Éric A. Cohen,Nathalie Grandvaux,Daniel Lamarre +13 more
TL;DR: A novel link between WNT signaling pathway and the modulation of retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-dependent innate immune responses is reported, confirming a novel regulation of antiviral innate immunity by a canonical-like WNT/CTNNB1 signaling pathway.
IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response.
Karin Fink,Lydie Martin,Espérance Mukawera,Stéfany Chartier,Xavier De Deken,Emmanuelle Brochiero,Françoise Miot,Nathalie Grandvaux +7 more
TL;DR: A novel delayed antiviral response in the airways is unveiled, initiated by the synergistic autocrine/paracrine action of IFNβ and TNFα, and signals through a non-canonical STAT2- and IRF9-dependent, but STAT1-independent cascade, which ultimately leads to the late induction of the DUOX2 NADPH oxidase expression.
Lung epithelial NOX/DUOX and respiratory virus infections.
TL;DR: The goal of the present review is to summarize current knowledge of the role of individual NOX/DUOX isoforms expressed in the lung epithelium in the context of respiratory virus infections so as to highlight potential opportunities for therapeutic intervention.
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