Karen Wright
Harvard University
90 Papers
280 Citations
Karen Wright is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Ependymoma. The author has an hindex of 23, co-authored 74 publications. Previous affiliations of Karen Wright include Dartmouth–Hitchcock Medical Center & Boston Children's Hospital.
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Papers
Cross-species genomics matches driver mutations and cell compartments to model ependymoma
Robert A. Johnson,Karen Wright,Helen Poppleton,Kumarasamypet M. Mohankumar,David Finkelstein,Stanley Pounds,Vikki Rand,Sarah Leary,Elsie White,Christopher J. Eden,Twala L. Hogg,Paul A. Northcott,Stephen C. Mack,Geoffrey Neale,Yong Dong Wang,Beth Coyle,Jennifer M. Atkinson,Mariko DeWire,Tanya A. Kranenburg,Yancey Gillespie,Jeffrey C. Allen,Thomas E. Merchant,F.A. Boop,Robert A. Sanford,Amar Gajjar,David W. Ellison,Michael D. Taylor,Richard Grundy,Richard J. Gilbertson +28 more
TL;DR: Comparison of matched mouse and human tumours revealed selective deregulation in the expression and copy number of genes that control synaptogenesis, pinpointing disruption of this pathway as a critical event in the production of this ependymoma subgroup.
The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants
Kristian W. Pajtler,Kristian W. Pajtler,Stephen C. Mack,Stephen C. Mack,Vijay Ramaswamy,Christian A. Smith,Hendrik Witt,Hendrik Witt,Amy M. Smith,Jordan R. Hansford,Katja von Hoff,Karen Wright,Eugene Hwang,Didier Frappaz,Yonehiro Kanemura,Maura Massimino,Cécile Faure-Conter,Piergiorgio Modena,Uri Tabori,Katherine E. Warren,Eric C. Holland,Koichi Ichimura,Felice Giangaspero,David Castel,Andreas von Deimling,Andreas von Deimling,Marcel Kool,Peter B. Dirks,Richard Grundy,Nicholas K. Foreman,Amar Gajjar,Andrey Korshunov,Andrey Korshunov,Jonathan L. Finlay,Richard J. Gilbertson,David W. Ellison,Kenneth Aldape,Thomas E. Merchant,Eric Bouffet,Stefan M. Pfister,Stefan M. Pfister,Michael D. Taylor +41 more
TL;DR: The major consensus among attendees was reached that treatment decisions for ependymoma (outside of clinical trials) should not be based on grading (II vs III), and molecular subgrouping should be part of all clinical trials henceforth.
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Pediatric low-grade gliomas: next biologically driven steps.
David T.W. Jones,Mark W. Kieran,Eric Bouffet,Sanda Alexandrescu,Pratiti Bandopadhayay,Miriam Bornhorst,David W. Ellison,Jason Fangusaro,Michael Fisher,Nicholas K. Foreman,Maryam Fouladi,Darren Hargrave,Cynthia Hawkins,Nada Jabado,Maura Massimino,Sabine Mueller,Giorgio Perilongo,Antoinette Schouten van Meeteren,Uri Tabori,Katherine E. Warren,Katherine E. Warren,Angela J. Waanders,David Walker,William A. Weiss,Olaf Witt,Karen Wright,Yuan Zhu,Daniel C. Bowers,Stefan M. Pfister,Roger J. Packer +29 more
TL;DR: The overall tone was positive, with a consensus that progress is being and will continue to be made, the scale of the challenge presented by this complex group of tumors was also acknowledged.
Distinct disease-risk groups in pediatric supratentorial and posterior fossa ependymomas
Catherine Godfraind,Joanna M. Kaczmarska,Mehmet Kocak,James Dalton,Karen Wright,Robert A. Sanford,F.A. Boop,Amar J. Gajjar,Thomas E. Merchant,David W. Ellison +9 more
TL;DR: Among children developing posterior fossa ependymomas treated with maximal surgical resection and conformal radiotherapy, key clinicopathological variables and chromosome 1q status can be used to define tiers of disease risk.
Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma
Nalin Gupta,Liliana Goumnerova,Peter E. Manley,Susan N. Chi,Donna Neuberg,Maneka Puligandla,Maneka Puligandla,Jason Fangusaro,Stewart Goldman,Stewart Goldman,Tadanori Tomita,Tord D. Alden,Arthur J. DiPatri,Joshua B. Rubin,Karen Gauvain,David D. Limbrick,Jeffrey R. Leonard,J. Russel Geyer,Sarah Leary,Samuel R. Browd,Zhihong Wang,Sandeep Sood,Anne Bendel,Anne Bendel,Mahmoud Nagib,Sharon Gardner,Matthias A. Karajannis,Matthias A. Karajannis,David H. Harter,Kanyalakshmi Ayyanar,William Gump,Daniel C. Bowers,Bradley E. Weprin,Tobey J. MacDonald,Dolly Aguilera,Barunashish Brahma,Nathan Robison,Erin Kiehna,Mark Krieger,Eric Sandler,Philipp R. Aldana,Ziad Khatib,John Ragheb,Sanjiv Bhatia,Sabine Mueller,Anu Banerjee,Amy Lee Bredlau,Sri Gururangan,Herbert E. Fuchs,Kenneth J. Cohen,George I. Jallo,Kathleen Dorris,Michael H. Handler,Melanie Comito,Mark S. Dias,Kellie J. Nazemi,Lissa C. Baird,Jeffrey R. Murray,Neal I. Lindeman,Jason L. Hornick,Hayley Malkin,Claire Sinai,Lianne Greenspan,Karen Wright,Karen Wright,Michael D. Prados,Pratiti Bandopadhayay,Keith L. Ligon,Mark W. Kieran +68 more
TL;DR: Surgical biopsy of DIPGs is technically feasible, associated with acceptable risks, and can provide biologic data that can inform treatment decisions, according to the authors.