Karen W. Dodson
Washington University in St. Louis
59 Papers
660 Citations
Karen W. Dodson is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Pilus & Bacterial adhesin. The author has an hindex of 29, co-authored 47 publications.
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Papers
A murine model of urinary tract infection
TL;DR: A protocol for a robust murine UTI model that allows for the study of uropathogens in an ideal setting and identifies important aspects of the host-pathogen interaction that determine the outcome of infection is described and provided.
Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist
Caitlin N. Spaulding,Roger D. Klein,Ségolène Ruer,Andrew L. Kau,Henry L. Schreiber,Zachary T. Cusumano,Karen W. Dodson,Jerome S. Pinkner,Daved H. Fremont,James W. Janetka,Han Remaut,Jeffrey I. Gordon,Scott J. Hultgren +12 more
TL;DR: It is shown that F17-like and type 1 pili promote intestinal colonization and show distinct binding to epithelial cells distributed along colonic crypts, and targeting FimH with M4284, a high-affinity inhibitory mannoside, reduces intestinal colonization of genetically diverse UPEC isolates, while simultaneously treating UTI, without notably disrupting the structural configuration of the gut microbiota.
Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor.
Karen W. Dodson,Jerome S. Pinkner,Thierry Rose,Göran Magnusson,Scott J. Hultgren,Gabriel Waksman +5 more
TL;DR: In this article, the crystal structures of a binary complex of the PapG receptor binding domain bound to GbO4 as well as the unbound form of the adhesin are presented.
273
Escherichia coli Biofilms Have an Organized and Complex Extracellular Matrix Structure
Chia S. Hung,Yizhou Zhou,Jerome S. Pinkner,Karen W. Dodson,Jan R. Crowley,John E. Heuser,Matthew George Chapman,Maria Hadjifrangiskou,Jeffrey P. Henderson,Scott J. Hultgren +9 more
TL;DR: It is shown that uropathogenic Escherichia coli (UPEC) strains produce a biofilm with a highly ordered and complex extracellular matrix (ECM) that protects biofilm bacteria from environmental insults and also makes the dissolution of biofilms very challenging.
Intracellular bacterial communities of uropathogenic Escherichia coli in urinary tract pathogenesis
TL;DR: Recent studies of uropathogenic Escherichia coli have found that it can carry out a complex developmental program within the superficial epithelial cells of the mouse bladder, forming intracellular bacterial communities with many biofilm-like properties.
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