Karen M. Overbye
Merck & Co.
6 Papers
94 Citations
Karen M. Overbye is an academic researcher from Merck & Co.. The author has contributed to research in topics: Nocathiacin I & DNA gyrase. The author has an hindex of 5, co-authored 6 publications.
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Papers
Antibiotics: where did we go wrong?
Karen M. Overbye,John F. Barrett +1 more
TL;DR: A decline in antibacterial drug discovery, coupled with increasing risk as a result of infections caused by drug-resistant bacterial pathogens, represents a clear public health threat.
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Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus
John W. Phillips,Michael A. Goetz,Scott K. Smith,Deborah L. Zink,Jon D. Polishook,Russell Onishi,Scott P. Salowe,Judyann Wiltsie,John J. Allocco,Janet M. Sigmund,Karen Dorso,Suzy Lee,Stephen Skwish,Mercedes de la Cruz,Jesús Martín,Francisca Vicente,Olga Genilloud,Jun Lu,Ronald E. Painter,Katherine Young,Karen M. Overbye,Robert G. K. Donald,Sheo B. Singh +22 more
TL;DR: Kibdelomycin is the first truly novel bacterial type II topoisomerase inhibitor with potent antibacterial activity discovered from natural product sources in more than six decades.
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Real-Time Monitoring of Bacterial Infection In Vivo: Development of Bioluminescent Staphylococcal Foreign-Body and Deep-Thigh-Wound Mouse Infection Models
Nelly A. Kuklin,Gregory D. Pancari,Timothy W. Tobery,Leslie Cope,Jesse J. Jackson,Charles Gill,Karen M. Overbye,Kevin P. Francis,Jun Yu,Donna L. Montgomery,Annaliesa S. Anderson,William L. Mcclements,Kathrin U. Jansen +12 more
TL;DR: The existing foreign-body and deep-wound mouse models of staphylococcal infection are adapted to allow real-time monitoring of the bacterial colonization of catheters or tissues and enables kinetic measurements of bacterial growth and clearance in each infected animal.
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Antibacterial evaluations of thiazomycin- a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
Sheo B. Singh,James L. Occi,Hiranthi Jayasuriya,Kithsiri Herath,Mary Motyl,Karen Dorso,Charles Gill,Emily Hickey,Karen M. Overbye,John F. Barrett,Prakash S. Masurekar +10 more
TL;DR: Thiazomycin possesses an oxazolidine ring in the amino-sugar residue that provides further opportunities for selective chemical modifications that are not feasible with other thiazolyl peptides and can potentially lead to semi-synthetic compounds that overcome problems that have hampered clinical development of this class of compounds.
High-yield expression, purification, and characterization of active, soluble Bacteroides fragilis metallo-beta-lactamase, CcrA.
TL;DR: Thermal denaturation studies using circular dichroism and fluorescence spectroscopy show that CcrA undergoes a transition at approximately 50 degrees C which corresponds to the transition temperature of catalytic activity, and the secondary structure of the protein and the catalytic apparatus are thus intimately linked.
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