Karen Choong
Boston University
9 Papers
57 Citations
Karen Choong is an academic researcher from Boston University. The author has contributed to research in topics: Dihydrotestosterone & Androgen. The author has an hindex of 8, co-authored 9 publications.
Chat about Author
Papers
Adverse Events Associated with Testosterone Administration
Shehzad Basaria,Andrea D. Coviello,Thomas G. Travison,Thomas W. Storer,Wildon Farwell,Wildon Farwell,Alan M. Jette,Richard Eder,Sharon L. Tennstedt,Jagadish Ulloor,Anqi Zhang,Karen Choong,Kishore M. Lakshman,Norman A. Mazer,Renee Miciek,Joanne B. Krasnoff,Ayan Elmi,Philip E. Knapp,Brad Brooks,Erica R. Appleman,Sheetal Aggarwal,Geeta Bhasin,Leif Hede-Brierley,Ashmeet Bhatia,Lauren Collins,Nathan K. LeBrasseur,Louis D. Fiore,Shalender Bhasin +27 more
TL;DR: In this population of older men with limitations in mobility and a high prevalence of chronic disease, the application of a testosterone gel was associated with an increased risk of cardiovascular adverse events.
1.4K
Clinical Meaningfulness of the Changes in Muscle Performance and Physical Function Associated With Testosterone Administration in Older Men With Mobility Limitation
Thomas G. Travison,Shehzad Basaria,Thomas W. Storer,Alan M. Jette,Renee Miciek,Wildon Farwell,Wildon Farwell,Karen Choong,Kishore M. Lakshman,Norman A. Mazer,Andrea D. Coviello,Philip E. Knapp,Jagadish Ulloor,Anqi Zhang,Brad Brooks,Ahn Hoa Nguyen,Richard Eder,Nathan K. LeBrasseur,Ayan Elmi,Erica R. Appleman,Leife Hede-Brierley,Geeta Bhasin,Ashmeet Bhatia,Antonio A. Lazzari,Samuel Davis,Pengsheng Ni,Lauren Collins,Shalender Bhasin +27 more
TL;DR: Testosterone administration in older men with mobility limitation was associated with patient-important improvements in muscle strength and stair-climbing power.
253
Emerging cardiometabolic complications of androgen deprivation therapy.
Karen Choong,Shehzad Basaria +1 more
TL;DR: Although its use has improved survival in a subset of patients, it also has negative consequences, and metabolic complications in these men such as insulin resistance, diabetes and metabolic syndrome are found.
33
Kinetic and thermodynamic characterization of dihydrotestosterone-induced conformational perturbations in androgen receptor ligand-binding domain.
Ravi Jasuja,Ravi Jasuja,Jagadish Ulloor,Christopher M. Yengo,Karen Choong,Andrei Y. Istomin,Dennis R. Livesay,Donald J. Jacobs,Ronald S. Swerdloff,Jaroslava Miksovska,Randy W. Larsen,Shalender Bhasin +11 more
TL;DR: DHT binding leads to energetic stabilization of AR-LBD domain and substantial rearrangement of residues distant from the ligand-binding pocket and molecular simulations demonstrated unique sensitivity of tyrosine and tryptophan residues during pressure unfolding with rearrangements of residues in the coactivator recruitment surfaces distant fromThe ligand -binding pocket.
19
F-18 FDG PET/CT imaging of endogenous Cushing syndrome.
Tatianie Jackson,Karen Choong,Jessica A. Eng,David McAneny,Rathan M. Subramaniam,Philip E. Knapp +5 more
TL;DR: In most cases of CS, elevated adrenocorticotropic hormone (ACTH) secretion results in excess adrenal gland cortisol secretion but usually this is from pituitary, not ectopic ACTH production.
5