Karen Beets
Katholieke Universiteit Leuven
6 Papers
19 Citations
Karen Beets is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Endothelium & SMAD. The author has an hindex of 6, co-authored 6 publications.
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Papers
Stalk Cell Phenotype Depends on Integration of Notch and Smad1/5 Signaling Cascades
Iván M. Moya,Lieve Umans,Elke Maas,Paulo N. G. Pereira,Karen Beets,Annick Francis,Ward Sents,Elizabeth J. Robertson,Christine L. Mummery,Danny Huylebroeck,An Zwijsen +10 more
TL;DR: In vivo evidence is provided for a regulatory loop between BMP/TGFβ-Smad1/5 and Notch signaling that orchestrates tip- versus stalk-cell selection and vessel plasticity.
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Single-cell transcriptome analysis of the Akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathy
Inge Van Hove,Lies De Groef,Bram Boeckx,Elodie Modave,Tjing-Tjing Hu,Karen Beets,Isabelle Etienne,Tine Van Bergen,Diether Lambrechts,Lieve Moons,Jean H.M. Feyen,Michaël Porcu +11 more
TL;DR: This study identifies molecular pathways underlying inflammatory, metabolic and oxidative stress-mediated changes in the Akimba mouse model of diabetic retinopathy and distinguishes distinct functional subtypes of inflammatory and macroglial cells.
Targeting RGD-binding integrins as an integrative therapy for diabetic retinopathy and neovascular age-related macular degeneration.
Inge Van Hove,Tjing Tjing Hu,Karen Beets,Tine Van Bergen,Isabelle Etienne,Alan W. Stitt,Elke Vermassen,Jean H.M. Feyen +7 more
TL;DR: In this article, the role of arginyl-glycyl-aspartic acid (Arg-Gly-Asp; RGD)-binding integrins in complex multifactorial retinal disorders like diabetic retinopathy (DR), age-related macular degeneration (AMD), glaucoma, dry eye disease and retinal vein occlusion is discussed.
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BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks.
Karen Beets,Michael W. Staring,Nathan Criem,Elke Maas,Niels Schellinx,Susana M. Chuva de Sousa Lopes,Lieve Umans,An Zwijsen +7 more
TL;DR: The data reveals the highly dynamic nature of BMP-SMAD mediated transcriptional regulation in time and space throughout the vascular tree, supporting that BMP -SMAD signalling can be a source of phenotypic diversity in some, but not all, healthy endothelium.
Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo
Andrea Conidi,Andrea Conidi,Silvia Cazzola,Silvia Cazzola,Karen Beets,Kathleen Coddens,Kathleen Coddens,Clara Collart,Clara Collart,F.M. Cornelis,Luk Cox,Debruyn Joke,Debruyn Joke,Mariya P. Dobreva,Ruben Dries,Ruben Dries,Camila V. Esguerra,Camila V. Esguerra,Annick Francis,Annick Francis,Abdelilah Ibrahimi,Abdelilah Ibrahimi,Roel Kroes,Roel Kroes,Flore Lesage,Flore Lesage,Elke Maas,Iván M. Moya,Paulo N. G. Pereira,Elke Stappers,Elke Stappers,Agata Stryjewska,Agata Stryjewska,Veronique van den Berghe,Veronique van den Berghe,Liesbeth Vermeire,Liesbeth Vermeire,Griet Verstappen,Griet Verstappen,Eve Seuntjens,Eve Seuntjens,Lieve Umans,An Zwijsen,Danny Huylebroeck,Danny Huylebroeck +44 more
TL;DR: This survey selected appropriate examples on the BMP-Smads, with emphasis on Smad1 and Smad5, and on a number of SIPs, i.e. the CPSF subunit Smicl, Ttrap (Tdp2) and Sip1 (Zeb2, Zfhx1b) from the authors' own research carried out in three different vertebrate models.