8 Papers
151 Citations
Karen Bean is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Superoxide dismutase & Paraquat. The author has an hindex of 5, co-authored 6 publications.
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Papers
Response of Pseudomonas aeruginosa to pyocyanin: mechanisms of resistance, antioxidant defenses, and demonstration of a manganese-cofactored superoxide dismutase.
TL;DR: Results demonstrate that P. aeruginosa resists pycyanin because of limited redox cycling of this compound and that under conditions favoring pyocyanin production, catalase and superoxide dismutase activities increase.
271
Preliminary observations on lactoferrin secretion in human vaginal mucus: variation during the menstrual cycle, evidence of hormonal regulation, and implications for infection with Neisseria gonorrhoeae
TL;DR: Variation in vaginal lactoferrin concentration may result in alterations in susceptibility to bacterial pathogens such as Neisseriae gonorrhoeae, and vaginal lact oferrin appears to be under hormonal control.
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Regulation of catalase in Neisseria gonorrhoeae. Effects of oxidant stress and exposure to human neutrophils.
TL;DR: The results suggest that catalase is an important defense for N. gonorrhoeae during attack by human neutrophils, and the rapid response of this enzyme to hydrogen peroxide should be taken into consideration in studies designed to evaluate the interaction between neutrophil and gonococci.
The role of hydroxyl radical in chromosomal and plasmid damage in Neisseria gonorrhoeae in vivo.
TL;DR: DNA and RNA damage in viable organisms exposed to intracellular redox stress is demonstrated and the critical role of hydroxyl radical in this process is confirmed.
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Exposure to myeloid and other mammalian cells increases Neisseria gonorrhoeae O2 utilization. Implications for pathogenesis
Bradley E. Britigan,D. Klapper,T. Svendsen,Karen Bean,Myron S. Cohen +4 more
- 01 Jan 1988
TL;DR: The promyelocytic HL-60 cell line (which cannot undergo a “respiratory burst”) induced a 2–3 fold increase in GC O2 consumption, independent of GC phenotype, secondary to a low molecular weight factor released by the cells which may be similar to that previously described in human serum.
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