Kara A. Scheibner
University of Maryland, Baltimore
12 Papers
204 Citations
Kara A. Scheibner is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Biology & microRNA. The author has an hindex of 11, co-authored 12 publications. Previous affiliations of Kara A. Scheibner include Johns Hopkins University School of Medicine.
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Papers
Hyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR2
Kara A. Scheibner,Michael A. Lutz,Sada Boodoo,Matthew J. Fenton,Jonathan D. Powell,Maureen R. Horton +5 more
TL;DR: It is demonstrated that LMW HA activates the innate immune response via TLR-2 in a MyD88-, IL-1R-associated kinase-, TNFR-associated factor-6-, protein kinase Cζ-, and NF-κB-dependent pathway and can act as an adjuvant promoting Ag-specific T cell responses in vivo in wild-type mice.
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Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile
Kimberly Cramer-Morales,Margaret Nieborowska-Skorska,Kara A. Scheibner,Michelle Padget,David Irvine,Tomasz Sliwinski,Tomasz Sliwinski,Kimberly Haas,Jae-Woong Lee,Huimin Geng,Darshan Roy,Artur Slupianek,Feyruz V. Rassool,Mariusz A. Wasik,Wayne E. Childers,Mhairi Copland,Markus Müschen,Curt I. Civin,Tomasz Skorski +18 more
TL;DR: Using mutagenesis and a peptide aptamer approach, RAD52 DNA binding domain I (RAD52-phenylalanine 79 [F79]) is pinpointed as a valid target to induce synthetic lethality in BRCA1- and/or BRCa2-deficient leukemias and carcinomas without affecting normal cells and tissues.
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Investigation of the roles of catalytic residues in serotonin N-acetyltransferase.
TL;DR: The functional properties of two histidines and a tyrosine postulated to be important in the mechanism of AANAT are probed and the relevant structural conformations related to the distinct alkyltransferase and acetyltransferase reactions catalyzed by AANat are proposed.
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c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase–Activated Leukemias
Nidal Muvarak,Shannon M. Kelley,Carine Robert,Maria R. Baer,Danilo Perrotti,Carlo Gambacorti-Passerini,Curt I. Civin,Kara A. Scheibner,Feyruz V. Rassool +8 more
TL;DR: It is demonstrated that the TK target c-MYC plays a role in transcriptional activation and subsequent expression of LIG3 and PARP1 and contributes to the increased error-prone repair observed in TK-activated leukemias.
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•Journal Article
Investigation of the roles of catalytic residues in serotonin n-acetyltransferase
TL;DR: In this article, the functional properties of two histidines (His-120 and His-122) and a tyrosine (Tyr-168) were probed based on prior x-ray structural and biochemical studies.
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