Kanghui Yang
Shandong University
14 Papers
85 Citations
Kanghui Yang is an academic researcher from Shandong University. The author has contributed to research in topics: Hydrogen bond & Neuraminidase. The author has an hindex of 6, co-authored 14 publications.
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Papers
Potential Targets and Their Relevant Inhibitors in Anti-influenza Fields
TL;DR: Several proven and potential anti-influenza targets are discussed, including viral factors (such as hemagglutinin, M2 ion channel protein), RNA-dependent RNA polymerase (RdRp), nucleoprotein (NP), non-structural protein (NS) and neuraminidase (NA), and their relevant inhibitors.
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Synthesis and biological evaluation of N-(4-hydroxy-3-mercaptonaphthalen-1-yl)amides as inhibitors of angiogenesis and tumor growth.
Fuming Xu,Yuping Jia,Qingli Wen,Xuejian Wang,Lei Zhang,Yingjie Zhang,Kanghui Yang,Wenfang Xu +7 more
TL;DR: Compound 6d, which possesses an ortho-nitro group at the benzene ring, exhibited potent inhibitory effect on the proliferation of HUVECs, A549, K562, PC-3, HCT116, MDA-MB-231 and MCF-7 cells, which supports the further investigation of this class of compounds as potential antiangiogenic and anticancer agents.
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Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors.
TL;DR: A series of novel chloramphenicol amine derivatives as aminopeptidase N (APN) /CD13 inhibitors are reported, showing similar APN inhibitory activity compared with Bestatin.
15
Design, synthesis and biological evaluation of novel l-lysine ureido derivatives as aminopeptidase N inhibitors
TL;DR: Two series of L-lysine ureido derivatives as APN inhibitors are designed and synthesized and one compound, 5d, showed similar inhibitory effect compared with Bestatin.
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The Effect of Different Species Aminopeptidase N Structure on the Activity Screening of Aminopeptidase N Inhibitor
TL;DR: The compound 16l could effectively inhibit the enzyme activity of porcine APN, but not homo sapien APN located on the surface of tumor cells, therefore, the activity screening of APN inhibitor using aminopeptidase N from Porcine should be only preliminary determination.
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