Kang Jin
University of Hong Kong
15 Papers
47 Citations
Kang Jin is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Teixobactin & Biology. The author has an hindex of 10, co-authored 14 publications. Previous affiliations of Kang Jin include Shandong University.
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Papers
Total synthesis of teixobactin.
Kang Jin,Iek Hou Sam,Kathy Hiu Laam Po,Du'an Lin,Ebrahim H. Ghazvini Zadeh,Sheng Chen,Yu Yuan,Xuechen Li +7 more
TL;DR: Teixobactin is reported as a promising first-in-class drug candidate for clinical development by a highly convergent Ser ligation approach and this strategy allows for several analogues of the natural product to be prepared.
P−B Desulfurization: An Enabling Method for Protein Chemical Synthesis and Site-Specific Deuteration
TL;DR: This method enables the clean desulfurization of peptides carrying post-translational modifications, such as phosphorylation and crotonylation, and features usage of common reagents, simplicity of operation, robustness, high yields, clean conversion, and versatile functionality compatibility with complex peptides/proteins.
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Cysteine/Penicillamine Ligation Independent of Terminal Steric Demands for Chemical Protein Synthesis.
TL;DR: The notable features of this method include its tolerance of steric hinderance from the side groups on either ligating terminus, allowing the flexible disconnection at sites that are otherwise difficult to functionalize and its expanded to selective desulfurization and one-pot ligation-desulfurizing reactions.
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Methylation of Daptomycin Leading to the Discovery of Kynomycin, a Cyclic Lipodepsipeptide Active against Resistant Pathogens
Hoi Yee Chow,Kathy Hiu Laam Po,Kathy Hiu Laam Po,Peng Gao,Pilar Blasco,Xiukun Wang,Congran Li,Lianwei Ye,Kang Jin,Kaichao Chen,Edward Chan,Xuefu You,Richard Y.T. Kao,Sheng Chen,Xuechen Li +14 more
TL;DR: The improved antimicrobial activity of kynomycin was demonstrated in in vitro time killing assay, in vivo wax worm model and different mouse infection models, and showed the promise of the future design and development of next-generation daptomycin-based antibiotics.
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Establishing the Structure-Activity Relationship of Daptomycin
Hoi Yee Chow,Kathy Hiu Laam Po,Kang Jin,Guanlin Qiao,Zhenquan Sun,Wenjie Ma,Xiyun Ye,Ning Zhou,Sheng Chen,Xuechen Li +9 more
TL;DR: From this study, a comprehensive structure-activity relationship of daptomycin is established which will lay the foundation for the further development of d aptomycin-based antibiotics.
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