Kan Yaguchi
Hokkaido University
11 Papers
7 Citations
Kan Yaguchi is an academic researcher from Hokkaido University. The author has contributed to research in topics: Centrosome & Centrosome duplication. The author has an hindex of 3, co-authored 8 publications.
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Papers
Uncoupling of DNA Replication and Centrosome Duplication Cycles Is a Primary Cause of Haploid Instability in Mammalian Somatic Cells.
TL;DR: An experimental method is developed that allows the re-coupling of DNA and centrosome cycles through the chronic extension of the G1/S phase without compromising cell proliferation using thymidine treatment/release cycles, and demonstrates the feasibility of modulation of haploid stability through artificial coordination between DNA and Centrosomes cycles in mammalian somatic cells.
Multivalent coiled-coil interactions enable full-scale centrosome assembly and strength
Manolo U Rios,Bryan D. Ryder,Beatriz Ferreira Gomes,Nicole Familiari,Kan Yaguchi,Jeffrey B. Woodruff +5 more
TL;DR: In this article , the authors use cross-linking mass spectrometry to identify interactions underlying supramolecular assembly of SPD-5, the main PCM scaffold protein in C. elegans.
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Tetraploidy-associated centrosome overduplication in mouse early embryos.
Kan Yaguchi,Takahiro Yamamoto,Ryo Matsui,Masaya Shimada,Atsuko Shibanuma,Keiko Kamimura,Toshiaki Koda,Ryota Uehara +7 more
TL;DR: The extra numbers of the centrioles and the centrosomes were observed more frequently in tetraploidized embryos during the blastocyst stage than in their diploid counterparts, demonstrating the generality of the newly found tetraPloidy-driven centrosome overduplication in mammalian non-cancer systems.
Uncoupling of DNA replication and centrosome duplication cycles is a primary cause of haploid instability in mammalian somatic cells
TL;DR: An experimental method is developed that allows the re-coupling of DNA and centrosome cycles through the chronic extension of the G1/S phase without compromising cell proliferation using thymidine treatment/release cycles, and demonstrates the feasibility of modulation of haploid stability through artificial coordination between DNA and Centrosomes cycles in mammalian somatic cells.
Ploidy-dependent change in cyclin D2 expression and sensitization to cdk4/6 inhibition in human somatic haploid cells.
Kan Yaguchi,Takahiro Yamamoto,Masaya Shimada,Rina Sugimoto,Kiminori Nakamura,Tokiyoshi Ayabe,Ryota Uehara +6 more
TL;DR: Lowering of cyclin D2 level in haploids is found by comparative transcriptome analysis between human isogenic haploid and diploid cell lines, indicating feasibility of selective growth suppression of haploid cells based on ploidy-linked gene regulation.
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