Kamel Khalili
Temple University
416 Papers
4.8K Citations
Kamel Khalili is an academic researcher from Temple University. The author has contributed to research in topics: JC virus & Biology. The author has an hindex of 71, co-authored 409 publications. Previous affiliations of Kamel Khalili include Drexel University & Beth Israel Deaconess Medical Center.
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Papers
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
Wenhui Hu,Rafal Kaminski,Fan Yang,Yonggang Zhang,Laura Cosentino,Fang Li,Biao Luo,David Alvarez-Carbonell,Yoelvis García-Mesa,Jonathan Karn,Xianming Mo,Kamel Khalili +11 more
TL;DR: The results suggest that Cas9/gRNA can be engineered to provide a specific, efficacious prophylactic and therapeutic approach against AIDS.
Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain.
Michael W. Ferenczy,Leslie J. Marshall,Christian D. S. Nelson,Walter J. Atwood,Avindra Nath,Kamel Khalili,Eugene O. Major +6 more
TL;DR: The study of JCV and the elucidation of the underlying causes of PML are important and active areas of research that may lead to new insights into immune function and host antiviral defense, as well as to potential new therapies.
404
CNS invasion by CD14+/CD16+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection
Tracy Fischer-Smith,Sidney Croul,Andrij E. Sverstiuk,C. Capini,Darryl Z. L'Heureux,Emmanuel G. Régulier,Max W. Richardson,Shohreh Amini,Susan Morgello,Kamel Khalili,Jay Rappaport +10 more
TL;DR: Higher levels of soluble CD14 (sCD14) were observed in patients with moderate-to-severe HIV dementia, suggesting the utility of sCD14 as a surrogate marker and sCDl4 may be useful for evaluating these conditions.
Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing.
Rafal Kaminski,Yilan Chen,Tracy Fischer,Ellen Tedaldi,Alessandro Napoli,Yonggang Zhang,Jonathan Karn,Wenhui Hu,Kamel Khalili +8 more
TL;DR: Gene editing using CRISPR/Cas9 may provide a new therapeutic path for eliminating HIV-1 DNA from CD4+ T-cells and potentially serve as a novel and effective platform toward curing AIDS.
In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models.
Chaoran Yin,Ting Zhang,Xiying Qu,Yonggang Zhang,Raj Putatunda,Xiao Xiao,Fang Li,Weidong Xiao,Huaqing Zhao,Shen Dai,Xuebin Qin,Xianming Mo,Won Bin Young,Kamel Khalili,Wenhui Hu +14 more
TL;DR: In vivo excision of HIV-1 proviral DNA by sgRNAs/saCas9 in solid tissues/organs can be achieved via AAV delivery, a significant step toward human clinical trials.
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