16 Papers
23 Citations
Kaiwen Kam is an academic researcher from Rosalind Franklin University of Medicine and Science. The author has contributed to research in topics: Central pattern generator & Population. The author has an hindex of 13, co-authored 16 publications. Previous affiliations of Kaiwen Kam include University of California, San Francisco & University of California, Los Angeles.
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Papers
Distinct Endocytic Pathways Control the Rate and Extent of Synaptic Vesicle Protein Recycling
Susan M. Voglmaier,Kaiwen Kam,Hua Yang,Doris L. Fortin,Zhaolin Hua,Roger A. Nicoll,Robert H. Edwards +6 more
TL;DR: It is found that vesicular glutamate transporter VGLUT1 interacts directly with endophilin, a component of the clathrin-dependent endocytic machinery, implicating the AP3 pathway specifically in compensatory endocytosis.
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Breathing control center neurons that promote arousal in mice
Kevin Yackle,Lindsay A. Schwarz,Kaiwen Kam,Kaiwen Kam,Jordan M. Sorokin,John R. Huguenard,Jack L. Feldman,Liqun Luo,Mark A. Krasnow +8 more
TL;DR: A small, molecularly defined neuronal subpopulation is found in this breathing rhythm generator that directly projects to a brain center that plays a key role in generalized alertness, attention, and stress and has a direct and dramatic influence on higher-order brain function.
The peptidergic control circuit for sighing
Peng Li,Wiktor A. Janczewski,Kevin Yackle,Kaiwen Kam,Kaiwen Kam,Silvia Pagliardini,Silvia Pagliardini,Mark A. Krasnow,Jack L. Feldman +8 more
TL;DR: Small neural subpopulations in a key breathing control centre, the retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG), express bombesin-like neuropeptide genes neuromedin B (Nmb) or gastrin-releasing peptide (Grp) and it is proposed that these overlapping peptidergic pathways comprise the core of a sigh control circuit that integrates physiological and perhaps emotional input to transform normal breaths into sighs.
Defining preBötzinger Complex Rhythm- and Pattern-Generating Neural Microcircuits In Vivo.
TL;DR: It is concluded that preinspiratory preBötC Dbx1(+) and SST(+) neurons primarily act to pattern respiratory motor output, and S ST(+)-neuron-mediated pathways and postsynaptic inhibition within preB ÖtC modulate breathing pattern.
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Facing the challenge of mammalian neural microcircuits: taking a few breaths may help
Jack L. Feldman,Kaiwen Kam +1 more
TL;DR: The preBotzinger complex sits at the core of the neural circuit generating respiratory rhythm in mammals as discussed by the authors, which is the brainstem nucleus responsible for regulating the respiratory rhythm of mammals.
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