Kaitlin Allen
University of California, Berkeley
38 Papers
241 Citations
Kaitlin Allen is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 12, co-authored 22 publications. Previous affiliations of Kaitlin Allen include Harvard University & Massachusetts Institute of Technology.
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Papers
Synchronized cycles of bacterial lysis for in vivo delivery
M. Omar Din,Tal Danino,Arthur Prindle,Matthew Skalak,Jangir Selimkhanov,Kaitlin Allen,Ellixis Julio,Eta Atolia,Lev S. Tsimring,Sangeeta N. Bhatia,Jeff Hasty +10 more
TL;DR: In this article, the authors used microfluidic devices to characterize the engineered lysis strain and demonstrate its potential as a drug delivery platform via co-culture with human cancer cells in vitro.
620
Programmable probiotics for detection of cancer in urine
Tal Danino,Arthur Prindle,Gabriel A. Kwong,Matthew Skalak,Howard J. Li,Kaitlin Allen,Jeff Hasty,Sangeeta N. Bhatia +7 more
TL;DR: The results demonstrate that probiotics can be programmed to safely and selectively deliver synthetic gene circuits to diseased tissue microenvironments in vivo and can noninvasively indicate the presence of liver metastasis by producing easily detectable signals in urine.
424
Synchronized cycles of bacterial lysis for in vivo delivery
M. Omar Din,Tal Danino,Arthur Prindle,Matthew Skalak,Jangir Selimkhanov,Kaitlin Allen,Ellixis Julio,Eta Atolia,Lev S. Tsimring,Sangeeta N. Bhatia,Jeff Hasty +10 more
- 01 Aug 2016
TL;DR: The combination of both circuit-engineered bacteria and chemotherapy leads to a notable reduction of tumour activity along with a marked survival benefit over either therapy alone, and establishes a methodology for leveraging the tools of synthetic biology to exploit the natural propensity for certain bacteria to colonize disease sites.
397
Programmable probiotics for detection of cancer in urine
Tal Danino,Arthur Prindle,Gabriel A. Kwong,Matthew Skalak,Howard J. Li,Kaitlin Allen,Jeff Hasty,Sangeeta N. Bhatia +7 more
- 01 May 2015
TL;DR: In this article, the authors used the safe and widely used probiotic Escherichia coli Nissle 1917 to develop an orally administered diagnostic that can noninvasively indicate the presence of liver metastasis by producing easily detectable signals in urine.
201
Natural Tolerance to Ischemia and Hypoxemia in Diving Mammals: A Review.
TL;DR: The current knowledge regarding the strategies marine mammals use to suppress inflammation and cope with oxidant generation potentially derived from diving-induced ischemia/reperfusion are reviewed.