Kaikai Chen
University of Cambridge
51 Papers
63 Citations
Kaikai Chen is an academic researcher from University of Cambridge. The author has contributed to research in topics: Nanopore & Chemistry. The author has an hindex of 13, co-authored 30 publications. Previous affiliations of Kaikai Chen include China University of Petroleum & Tsinghua University.
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Papers
Digital Data Storage Using DNA Nanostructures and Solid-State Nanopores.
TL;DR: A high-resolution integrated nanopore system for identifying DNA nanostructures that has the capability of distinguishing attached short DNA hairpins with only a stem length difference along a DNA double strand named the DNA carrier is shown.
Nanopore-Based DNA Hard Drives for Rewritable and Secure Data Storage.
TL;DR: DNA hard drives (DNA-HDs) are introduced based on DNA nanotechnology and nanopore sensing as a rewritable molecular memory system, allowing for storing, operating and reading data in the changeable three-dimensional structure of DNA.
Ionic Current-Based Mapping of Short Sequence Motifs in Single DNA Molecules Using Solid-State Nanopores
Kaikai Chen,Kaikai Chen,Matyas Juhasz,Felix Gularek,Elmar Weinhold,Yu Tian,Ulrich F. Keyser,Nicholas A. W. Bell +7 more
TL;DR: An ionic current-based method for determining the positions of short sequence motifs in double-stranded DNA molecules with solid-state nanopores, providing a simple, generic single-molecule detection platform enabling DNA characterization in an electrical format suited for portable devices for potential diagnostic applications.
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Dynamics of driven polymer transport through a nanopore
Kaikai Chen,Ining A. Jou,Niklas Ermann,Murugappan Muthukumar,Ulrich F. Keyser,Nicholas A. W. Bell,Nicholas A. W. Bell +6 more
TL;DR: A study of the dynamics of polymer translocation through synthetic nanopores provides a direct observation of tension propagation—a non-equilibrium description of the process of unfolding that a polymer undergoes during translocation.
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Multiplexed DNA Identification Using Site Specific dCas9 Barcodes and Nanopore Sensing.
Nicole E. Weckman,Niklas Ermann,Richard Gutierrez,Kaikai Chen,James E. Graham,Ran Tivony,Andrew John Heron,Ulrich F. Keyser +7 more
TL;DR: This work systematically demonstrate the use of highly specific dCas9 probes to create unique barcodes on the DNA that can be read out using nanopore sensors, forming the basis of a fast and versatile assay for multiplexed DNA sensing applications in complex samples.