Kaia Mattioli
Harvard University
19 Papers
2 Citations
Kaia Mattioli is an academic researcher from Harvard University. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 5, co-authored 12 publications. Previous affiliations of Kaia Mattioli include Massachusetts Institute of Technology & Brigham and Women's Hospital.
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Papers
Chromatin environment, transcriptional regulation, and splicing distinguish lincRNAs and mRNAs.
Marta Melé,Kaia Mattioli,Kaia Mattioli,William Mallard,William Mallard,David M Shechner,David M Shechner,Chiara Gerhardinger,Chiara Gerhardinger,John L. Rinn,John L. Rinn,John L. Rinn +11 more
TL;DR: It is found that lincRNAs promoters are depleted of transcription factor (TF) binding sites, yet enriched for some specific factors such as GATA and FOS relative to mRNA promoters, and H3K9me3-a histone modification typically associated with transcriptional repression-is more enriched at the promoters of active lincRNA loci than at those of active mRNAs.
High-throughput functional analysis of lncRNA core promoters elucidates rules governing tissue specificity.
Kaia Mattioli,Pieter-Jan Volders,Pieter-Jan Volders,Chiara Gerhardinger,Chiara Gerhardinger,James Lee,James Lee,Philipp G. Maass,Philipp G. Maass,Marta Melé,Marta Melé,Marta Melé,John L. Rinn +12 more
TL;DR: It is suggested that high TF motif density serves as a robust mechanism to increase promoter activity at the expense of tissue specificity, and 22% of common SNPs in core promoter regions have significant regulatory effects.
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Cis and trans effects differentially contribute to the evolution of promoters and enhancers
Kaia Mattioli,Winona Oliveros,Chiara Gerhardinger,Daniel Andergassen,Philipp G. Maass,John L. Rinn,Marta Melé +6 more
TL;DR: This work uses massively parallel reporter assays to directly measure the transcriptional outputs of thousands of individual regulatory elements in embryonic stem cells and finds that cis effects are widespread across transcribed regulatory elements, and the strongest trans effects are associated with the disruption of motifs recognized by strong transcriptional activators.
Whole genome sequencing delineates regulatory, copy number, and cryptic splice variants in early onset cardiomyopathy
Robert Lesurf,Abdelrahman Fekry Abdelrahman Said,Oyediran Akinrinade,Jeroen Breckpot,Kathleen Delfosse,Ting Liu,Roderick Yao,Gabrielle Persad,Fintan McKenna,Ramil R. Noche,Winona Oliveros,Kaia Mattioli,Anastasia Miron,Qian Yang,Guoliang Meng,M. Yue,Wilson W L Sung,Bhooma Thiruvahindrapuram,Jane Lougheed,Erwin Oechslin,Tapas Mondal,Lynn Bergin,John Smythe,Shashank Jayappa,Vinay J. Rao,Jayaprakash Shenthar,Perundurai S. Dhandapany,Christopher Semsarian,Robert G. Weintraub,Richard D. Bagnall,Jodie Ingles,Marta Mele,Philipp Maass,James H Ellis,Stephen W. Scherer,Seema Mital +35 more
TL;DR: In this paper , the authors analyzed whole-genome sequencing (WGS) data in a discovery cohort of 209 pediatric CMP patients and 1953 independent replication genomes and exomes and provided strong evidence for the genomic contribution of functionally active variants in new genes and in regulatory elements of known CMP genes to early onset CMP.
Genome-wide CRISPR interference screen identifies long non-coding RNA loci required for differentiation and pluripotency
Jeffrey R. Haswell,Jeffrey R. Haswell,Kaia Mattioli,Chiara Gerhardinger,Chiara Gerhardinger,Philipp G. Maass,Daniel J. Foster,Daniel J. Foster,Paola Peinado,Xiaofeng Wang,Pedro P. Medina,John L. Rinn,Frank J. Slack +12 more
TL;DR: In this article, the first described human embryonic stem cell (hESC) lines to repress (CRISPRi) or activate CRISPRa transcription during differentiation into all three germ layers, facilitating the modulation of lncRNA expression during early development.
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