Kai Xu
Tsinghua University
4 Papers
Kai Xu is an academic researcher from Tsinghua University. The author has contributed to research in topics: Chromatin & Maternal to zygotic transition. The author has an hindex of 4, co-authored 4 publications.
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Papers
Resetting histone modifications during human parental-to-zygotic transition
Weikun Xia,Jiawei Xu,Guang Yu,Guidong Yao,Kai Xu,Xueshan Ma,Nan Zhang,Bofeng Liu,Tong Li,Zili Lin,Xia Chen,Lijia Li,Qiujun Wang,Dayuan Shi,Senlin Shi,Yile Zhang,Wenyan Song,Haixia Jin,Linli Hu,Zhiqin Bu,Yang Wang,Jie Na,Wei Xie,Yingpu Sun +23 more
TL;DR: By combining chromatin and transcriptome maps, the data unveil a priming phase connecting human parental-to-zygotic epigenetic transition and transcription circuitry and asymmetric H3K27me3 patterning during early lineage specification.
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Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos
Zhenhai Du,Hui Zheng,Yumiko K Kawamura,Ke Zhang,Johanna Gassler,Sean Powell,Qianhua Xu,Zili Lin,Kai Xu,Qian Zhou,Evgeniy A. Ozonov,Nathalie Véron,Bo Huang,Lijia Li,Guang Yu,Ling Liu,Wan Kin Au Yeung,Peizhe Wang,Lei Chang,Qiujun Wang,Aibin He,Yujie Sun,Jie Na,Qing-Yuan Sun,Hiroyuki Sasaki,Kikuë Tachibana,Kikuë Tachibana,Antoine H.F.M. Peters,Antoine H.F.M. Peters,Wei Xie +29 more
TL;DR: A critical role of Polycomb is revealed in regulating chromatin architecture during mammalian oocyte growth and early development using low-input Hi-C (genome-wide chromatin conformation capture) data.
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The landscape of RNA Pol II binding reveals a stepwise transition during ZGA.
Bofeng Liu,Qianhua Xu,Qiujun Wang,Su Feng,Fangnong Lai,Peizhe Wang,Fangyuan Zheng,Yunlong Xiang,Jingyi Wu,Junwei Nie,Cui Qiu,Weikun Xia,Lijia Li,Guang Yu,Zili Lin,Kai Xu,Zhuqing Xiong,Feng Kong,Ling Liu,Chunyi Huang,Yang Yu,Jie Na,Wei Xie +22 more
TL;DR: It is found that Pol II undergoes ‘loading, ‘pre-configuration’, and ‘production’ during the transition fromMinor ZGA to major ZGA, and minor ZGA has a key role in the pre- configuration of transcription machinery and chromatin for genome activation.
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Analysis of Genome Architecture during SCNT Reveals a Role of Cohesin in Impeding Minor ZGA.
Ke Zhang,Dan-Ya Wu,Hui Zheng,Yao Wang,Qiao-Ran Sun,Xin Liu,Li-Yan Wang,Wen-Jing Xiong,Qiujun Wang,James D.P. Rhodes,Kai Xu,Lijia Li,Zili Lin,Guang Yu,Weikun Xia,Bo Huang,Zhenhai Du,Yao Yao,Kim Nasmyth,Robert J. Klose,Yi-Liang Miao,Wei Xie +21 more
TL;DR: Multi-step reprogramming of 3D chromatin architecture during SCNT is revealed and dual roles of cohesin in TAD formation and minor zygotic genome activation genes are support and minor ZGA repression is found.
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