12 Papers
18 Citations
Kai Wu is an academic researcher from University of Medicine and Health Sciences. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 3, co-authored 6 publications.
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Papers
Engineering an alcohol dehydrogenase with enhanced activity and stereoselectivity toward diaryl ketones: reduction of steric hindrance and change of the stereocontrol element
TL;DR: Engineering an alcohol dehydrogenase with enhanced activity and stereoselectivity toward diaryl ketones: reduction of steric hindrance and change of the stereocontrol element.
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Three novel chromanones with biological activities from the endophytic fungus Phomopsis CGMCC No. 5416.
TL;DR: Three undescribed chromanones (1–3) and two known chromanone (4 and 5) were isolated from the culture of endophytic fungus Phomopsis CGMCC No. 5416 from the stems of Achyranthes bidentata and their structures were determined by spectroscopic analysis.
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Imine Reductases: Multifunctional Biocatalysts with Varying Active Sites and Catalytic Mechanisms
Kai Wu,Jun-Jian Huang,Lei Shao +2 more
TL;DR: The catalytic mechanisms reported for IRED-catalyzed asymmetric reductive amination (RA), conjugate reduction (CR) and RA activity by a single IRED has been reported for the preparation of valuable amine diastereomers as discussed by the authors .
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Efficient synthesis of an antiviral drug intermediate using an enhanced short-chain dehydrogenase in an aqueous-organic solvent system
TL;DR: Results show that muSDR may be a valuable biocatalyst for future industrial applications after optimization of expression and reaction conditions and reduced 15 ketones with excellent enantioselectivity, indicating broad substrate acceptance.
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A novel biologically active xylaphenoside from the endophytic fungus Xylaria CGMCC No.5410
TL;DR: A novel 3,4-dihydroisocoumarin glycoside was obtained from the culture of endophytic fungal Xylaria CGMCC No.5410 from the leaves of Selaginella moellendorffii Hieron together with five known compounds, which showed different antimicrobial, anti-tumor, or anti-HIV-1 activities.
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