Kai Wu
16 Papers
7 Citations
Kai Wu is an academic researcher. The author has contributed to research in topics: Medicine & Messenger RNA. The author has an hindex of 2, co-authored 3 publications.
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Papers
mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron
Matthew Gagne,Juan I. Moliva,Kathryn E. Foulds,Shayne Andrew,Barbara J. Flynn,Anne P. Werner,Danielle A Wagner,I-Ting Teng,Bob C. Lin,Christopher Brooks Moore,Nazaire Jean-Baptiste,Robin E. Carroll,Stephanie L. Foster,Mit Patel,Madison Ellis,Venkata Viswanadh Edara,Nahara Vargas Maldonado,Mahnaz Minai,Lauren McCormick,Christopher Cole Honeycutt,Bianca M. Nagata,Kevin W. Bock,Caitlyn N. M. Dulan,Jamilet Cordon,Dillon R. Flebbe,John Paul Todd,Elizabeth McCarthy,Laurent Pessaint,Alex Van Ry,Brandon Narvaez,Daniel Valentin,Anthony Cook,Alan Dodson,Katelyn Steingrebe,Saule Nurmukhambetova,Sucheta Godbole,Amy R. Henry,Farida Laboune,Jesmine Roberts-Torres,Cynthia G. Lorang,Shivani G. Amin,Jessica F. Trost,M. Naisan,Manjula Basappa,J. B. Willis,Lingshu Wang,Wei Shi,Nicole A. Doria-Rose,Yi Zhang,Eun Sung Yang,Kwanyee Leung,Sijy O'Dell,R. Schmidt,Adam S. Olia,Cuiping Liu,Darcy R. Harris,Gwo-Yu Chuang,Guillaume Stewart-Jones,Isabella Renzi,Yen-Ting Lai,Agata Malinowski,Kai Wu,John R. Mascola,Andrea Carfi,Peter D. Kwong,Darin K. Edwards,Mark A. Lewis,Hanne Andersen,Kizzmekia S. Corbett,Martha Nason,Adrian B. McDermott,Mehul S. Suthar,Ian N. Moore,Mario Roederer,Nancy J. Sullivan,Daniel C. Douek,Robert A. Seder +76 more
TL;DR: In this article , the authors showed that boosting with Omicron-matched vaccines would enhance protection, but it is unclear whether boosting with omicron matched vaccines would improve protection.
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Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant in mice
Suzanne M. Scheaffer,Diana Lee,Bradley M. Whitener,Baoling Ying,Kai Wu,Chieh Liang,Hardik Jani,Philippa Martin,Nicholas J. Amato,Laura E. Avena,Daniela Montes Berrueta,R. Schmidt,Sijy O'Dell,Arshan Nasir,Gwo-Yu Chuang,Guillaume Stewart-Jones,Richard A. Koup,Nicole A. Doria-Rose,Andrea Carfi,Sayda Elbashir,Larissa B. Thackray,Darin K. Edwards,Michael S. Diamond +22 more
TL;DR: In this paper , the authors evaluated the immunogenicity and protective efficacy of two, recently authorized, bivalent COVID-19 vaccines that contain two mRNAs encoding Wuhan-1 and either BA.4/5 (mRNA-1273.222) spike proteins.
Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice
Baoling Ying,Suzanne M. Scheaffer,Bradley M. Whitener,Chieh Liang,Oleksandr Dmytrenko,Samantha Mackin,Kai Wu,Diana Lee,Laura E. Avena,Zhenlu Chong,James Brett Case,LingZhi Ma,Thu Dang Kim,Caralyn E Sein,Angela Woods,Daniela Montes Berrueta,Gwo-Yu Chang,Guillaume Stewart-Jones,Isabella Renzi,Yen-Ting Lai,Agata Malinowski,Andrea Carfi,Sayda Elbashir,Darin K. Edwards,Larissa B. Thackray,Michael S. Diamond +25 more
TL;DR: In this paper , the authors evaluated the effect of Moderna mRNA-1273 vaccine against Omicron lineage variants (BA.1, BA.2, and BA.1) before or after boosting.
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Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant
Suzanne M. Scheaffer,Diana Lee,Bradley M. Whitener,Baoling Ying,Kai Wu,Hardik Jani,Philippa Martin,Nicholas J. Amato,Laura E. Avena,Daniela Montes Berrueta,R. Schmidt,Sijy O'Dell,Arshan Nasir,Gwo-Yu Chuang,Guillaume Stewart-Jones,Richard A. Koup,Nicole A. Doria-Rose,Andrea Carfi,Sayda Elbashir,Larissa B. Thackray,Darin K. Edwards,Michael S. Diamond +21 more
TL;DR: Boosting with bivalent Omicron-based mRNA- 1273.214 or mRNA-1273.222 vaccines enhances immunogenicity and protection against currently circulating SARS-CoV-2 strains.
Human Cytomegalovirus mRNA-1647 Vaccine Candidate Elicits Potent and Broad Neutralization and Higher Antibody-Dependent Cellular Cytotoxicity Responses Than the gB/MF59 Vaccine.
Xintao Hu,Krithika P. Karthigeyan,S. Herbek,Sarah M. Valencia,Jennifer A. Jenks,Helen S. Webster,I. Miller,Megan Connors,Justin Pollara,Caroline Andy,Linda M Gerber,E. Walter,Kathryn M. Edwards,David I. Bernstein,Jacob Hou,Matthew J. Koch,Lori Panther,Andrea Carfi,Kai Wu,Sallie R. Permar +19 more
TL;DR: Overall, mRNA-1647 vaccination induced polyfunctional and durable HCMV-specific antibody responses, with lower gB-specific IgG responses but higher neutralization and ADCC responses compared to the gB/MF59 vaccine.
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