Kai Licha
Free University of Berlin
109 Papers
896 Citations
Kai Licha is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Chemistry & Cyanine. The author has an hindex of 36, co-authored 100 publications. Previous affiliations of Kai Licha include Bayer HealthCare Pharmaceuticals & Humboldt University of Berlin.
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Papers
Dendritic polyglycerol sulfates as multivalent inhibitors of inflammation
Jens Dernedde,Alexandra Rausch,Marie Weinhart,Sven Enders,Rudolf Tauber,Kai Licha,Michael Schirner,Ulrich Zügel,Arne von Bonin,Rainer Haag +9 more
TL;DR: Synthetic dendritic polyglycerol sulfates (dPGS) are investigated as macromolecular inhibitors that operate via a multivalent binding mechanism mimicking naturally occurring ligands that may be used for the treatment of inflammatory diseases.
273
Functional and Structural Characterization of Synthetic HIV-1 Vpr That Transduces Cells, Localizes to the Nucleus, and Induces G2 Cell Cycle Arrest
Peter Henklein,Karsten Bruns,Michael P. Sherman,Uwe Tessmer,Kai Licha,Jeffrey B. Kopp,Carlos M. C. de Noronha,Warner C. Greene,Victor Wray,Ulrich Schubert,Ulrich Schubert +10 more
TL;DR: The production of synthetic Vpr was described that permitted the first studies on the structure and folding of the full-length protein, suggesting that the in vivo folding of Vpr may require structure-stabilizing interacting factors such as previously described interacting cellular and viral proteins or nucleic acids.
120
Macromolecular Contrast Agents for Optical Imaging of Tumors: Comparison of Indotricarbocyanine-labeled Human Serum Albumin and Transferrin¶
Andreas Becker,Bjorn Riefke,Bernd Ebert,Uwe Sukowski,Herbert Rinneberg,Wolfhard Semmler,Kai Licha +6 more
TL;DR: It is concluded that ITCC-labeled Tf and HSA can serve as macromolecular contrast agents for the optical imaging of tumors, with Tf-ITCC showing higher efficiency.
118
Development of efficient acid cleavable multifunctional prodrugs derived from dendritic polyglycerol with a poly(ethylene glycol) shell
TL;DR: Doxorubsicin polyglycerol conjugates with a high drug loading ratio showed clearly improved antitumor efficacy over doxorubicin in an ovarian xenograft tumor model (A2780) inducing transient complete remissions thus demonstrating the potential of developing efficient multifunctional dendritic drug delivery using the modular approach.
112
Synthesis, Reductive Cleavage, and Cellular Interaction Studies of Biodegradable, Polyglycerol Nanogels
TL;DR: This study highlights the great potential of these particles to function as sophisticated nanotransporters that deliver cargo to a certain tissue or cell target and then biodegrade into smaller fragments which would be cleared from the body by the kidney.