Kai Hu
Imperial College London
35 Papers
216 Citations
Kai Hu is an academic researcher from Imperial College London. The author has contributed to research in topics: Immunogenicity & Immune system. The author has an hindex of 14, co-authored 31 publications. Previous affiliations of Kai Hu include St George's, University of London & Chinese Academy of Sciences.
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Papers
Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice.
Paul F. McKay,Kai Hu,Anna K. Blakney,Karnyart Samnuan,Jonathan C Brown,Rebecca Penn,Jie Zhou,Clément R. Bouton,Paul Rogers,Krunal Polra,Paulo J. C. Lin,Christopher Barbosa,Ying K. Tam,Wendy S. Barclay,Robin J. Shattock +14 more
TL;DR: The authors develop a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle as a vaccine candidate and show induction of neutralization antibody titers in mice that are comparable to titer in convalescent sera of patients.
CCL19 and CCR7 Expression, Signaling Pathways, and Adjuvant Functions in Viral Infection and Prevention.
TL;DR: The impacts of CCL19 and CCR7 expression on the regulation of viral pathogenesis with an emphasis on the corresponding signaling pathways and adjuvant mechanisms are summarized.
Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice.
Alexandra J. Spencer,Paul F. McKay,Sandra Belij-Rammerstorfer,Marta Ulaszewska,Cameron Bissett,Kai Hu,Karnyart Samnuan,Anna K. Blakney,Daniel B. Wright,Hannah Sharpe,Ciaran Gilbride,A Truby,Elizabeth R. Allen,Sarah C. Gilbert,Robin J. Shattock,Teresa Lambe +15 more
TL;DR: In this paper, the authors present a detailed description of the immune response, in mice, following vaccination with a self-amplifying RNA (saRNA) vaccine and an adenoviral vectored vaccine (ChAdOx1 nCoV-19/AZD1222) against SARS CoV-2 mediated disease.
Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer.
Anna K. Blakney,Yunqing Zhu,Paul F. McKay,Clément R. Bouton,Jonathan Yeow,Jiaqing Tang,Kai Hu,Karnyart Samnuan,Christopher L. Grigsby,Robin J. Shattock,Molly M. Stevens,Molly M. Stevens +11 more
TL;DR: It is demonstrated that pABOL enhances protein expression and cellular uptake via both intramuscular and intradermal injection compared to commercially available polymers in vivo and that intamuscular injection confers complete protection against influenza challenge.
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Polymeric and lipid nanoparticles for delivery of self-amplifying RNA vaccines.
Anna K. Blakney,Paul F. McKay,Kai Hu,Karnyart Samnuan,Nikita Jain,Andrew F. Brown,Anitha Thomas,Paul Rogers,Krunal Polra,Hadijatou Sallah,Jonathan Yeow,Yunqing Zhu,Molly M. Stevens,Andrew Geall,Robin J. Shattock +14 more
TL;DR: In this article, the role of biomaterials in vaccine immunogenicity is investigated, including lipid nanoparticles (LNP), polyplexes and cationic nanoemulsions, and the results indicate that delivery systems and routes of administration may fulfill different delivery niches within the field of saRNA genetic medicines.
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