12 Papers
3 Citations
Kai Chen is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: Autophagy & Klotho. The author has an hindex of 10, co-authored 12 publications. Previous affiliations of Kai Chen include University of South Dakota.
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Papers
Diminished Autophagy Limits Cardiac Injury in Mouse Models of Type 1 Diabetes
Xianmin Xu,Satoru Kobayashi,Kai Chen,Derek Timm,Paul A. Volden,Yuan Huang,James Gulick,Zhenyu Yue,Jeffrey Robbins,Paul N. Epstein,Qiangrong Liang +10 more
TL;DR: The findings demonstrate that the diminished autophagy is an adaptive response that limits cardiac dysfunction in type 1 diabetes, presumably through up-regulation of alternative autophagic and mitophagy.
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AMP Activated Protein Kinase Is Indispensable for Myocardial Adaptation to Caloric Restriction in Mice
Kai Chen,Satoru Kobayashi,Xianmin Xu,Benoit Viollet,Benoit Viollet,Benoit Viollet,Qiangrong Liang +6 more
TL;DR: It is demonstrated that without AMPK, CR triggers adverse effects that can lead to cardiac dysfunction, suggesting that AMPK signaling pathway is indispensible for energy homeostasis and myocardial adaptation to CR, a dietary intervention that normally produces beneficial cardiac effects.
AAV Delivery of Tumor Necrosis Factor-α Short Hairpin RNA Attenuates Cold-Induced Pulmonary Hypertension and Pulmonary Arterial Remodeling
TL;DR: In this article, RNA interference silencing of tumor necrosis factor (TNF)-α decreases cold-induced macrophage infiltration, pulmonary hypertension (PH), and pulmonary arterial (PA) remodeling.
•Journal Article
Abstract 17570: Inducible Pluripotent Stem Cell-Derived Extracellular Vesicles Mitigates Aging-Associated Arterial Stiffness and Hypertension
TL;DR: Ageing is a major risk factor for the development of hypertension and arterial stiffness and this study was designed to assess the effect of indicible pluripotent stem cells (iPSC)-derived e...
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