Kaberniuk Aa
Albert Einstein College of Medicine
22 Papers
65 Citations
Kaberniuk Aa is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Diphtheria toxin & Protein subunit. The author has an hindex of 8, co-authored 22 publications. Previous affiliations of Kaberniuk Aa include National Academy of Sciences of Ukraine.
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Papers
Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe
Junjie Yao,Kaberniuk Aa,Lei Li,Daria M. Shcherbakova,Ruiying Zhang,Lidai Wang,Lidai Wang,Guo Li,Vladislav V. Verkhusha,Vladislav V. Verkhusha,Lihong V. Wang +10 more
TL;DR: A reversibly switchable nonfluorescent bacterial phytochrome for use in multiscale photoacoustic imaging, BphP1, with the most red-shifted absorption among genetically encoded probes is described, which enabled differential imaging with substantially decreased background signals, enhanced detection sensitivity, increased penetration depth and improved spatial resolution.
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Natural Photoreceptors as a Source of Fluorescent Proteins, Biosensors, and Optogenetic Tools
TL;DR: Optogenetic tools of various origins, such as LOV and BLUF (blue-light-utilizing flavin adenine dinucleotide) domains, cryptochromes, and phytochromes, enabling control of versatile cellular processes are provided.
186
Single-component near-infrared optogenetic systems for gene transcription regulation.
Kaberniuk Aa,Mikhail Baloban,Mikhail Monakhov,Daria M. Shcherbakova,Vladislav V. Verkhusha,Vladislav V. Verkhusha +5 more
TL;DR: In this paper, a single-component near-IR system, iLight, was developed from a bacterial phytochrome that they use to control gene transcription in bacterial and mammalian cells.
Near-infrared light-controlled systems for gene transcription regulation, protein targeting and spectral multiplexing.
TL;DR: Two protocols are presented that use a NIR-responsive bacterial phytochrome BphP1-QPAS1 optogenetic pair for regulation of gene transcription and another for control of protein localization that allows tridirectional protein translocation among the cytoplasm, nucleus and plasma membrane.
moxMaple3: a Photoswitchable Fluorescent Protein for PALM and Protein Highlighting in Oxidizing Cellular Environments
TL;DR: The engineering of a monomeric photoswitchable FP, moxMaple3, for use in oxidizing cellular environments, especially the eukaryotic secretory pathway is described, and a point mutation to replace a cysteine substantially improved the yield of correctly folded FP capable of chromophore formation, regardless of cellular environment.