17 Papers
50 Citations
Ka-Tim Choy is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Virus & Neuraminidase. The author has an hindex of 9, co-authored 12 publications. Previous affiliations of Ka-Tim Choy include University of Hong Kong.
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Papers
Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro.
Ka-Tim Choy,Alvina Y L Wong,Prathanporn Kaewpreedee,Sin Fun Sia,Dongdong Chen,Kenrie Pui Yan Hui,Daniel Ka Wing Chu Chu,Michael C. W. Chan,Pak Hang Peter Cheung,Xuhui Huang,Malik Peiris,Hui-Ling Yen +11 more
TL;DR: In vitro antiviral effect of compounds that were previously reported to inhibit coronavirus replication and compounds that are currently under evaluation in clinical trials for SARS-CoV-2 patients are evaluated.
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Resistance to Neuraminidase Inhibitors Conferred by an R292K Mutation in a Human Influenza Virus H7N9 Isolate Can Be Masked by a Mixed R/K Viral Population
Hui-Ling Yen,JL McKimm-Breschkin,Ka-Tim Choy,Diana D. Y. Wong,Peter Pak-Hang Cheung,Jie Zhou,Iris H. Y. Ng,Hongbo Zhu,Hongbo Zhu,Richard J. Webby,Yi Guan,Yi Guan,Robert G. Webster,Joseph S. M. Peiris +13 more
TL;DR: The results confirmed that the NA R292K mutation confers resistance to oseltamivir, peramivIR, and zanamvir in the novel human H7N9 viruses.
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Transmission of H7N9 Influenza Viruses with a Polymorphism at PB2 Residue 627 in Chickens and Ferrets
Geraldine S. M. Luk,Connie Y. H. Leung,Sin Fun Sia,Ka-Tim Choy,Jie Zhou,Candy C. K. Ho,Peter Pak-Hang Cheung,Elaine F. Lee,Chris K. L. Wai,Pamela C. H. Li,Sin-Ming Ip,Leo L.M. Poon,William G. Lindsley,Malik Peiris,Hui-Ling Yen +14 more
TL;DR: The results suggest direct contact as the main mode for H7N9 transmission and identify the PB2-V627 genotype with uncompromised fitness and transmissibility in both avian and mammalian species.
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The R292K Mutation That Confers Resistance to Neuraminidase Inhibitors Leads to Competitive Fitness Loss of A/Shanghai/1/2013 (H7N9) Influenza Virus in Ferrets
Hui-Ling Yen,Jie Zhou,Ka-Tim Choy,Sin Fun Sia,Ooiean Teng,Iris H. Y. Ng,Vicky J. Fang,Yunwen Hu,Wei Wang,Benjamin J. Cowling,John M. Nicholls,Yi Guan,Joseph S. M. Peiris +12 more
TL;DR: The NA inhibitor-resistant H7N9 virus with the NA-R292K mutation may transmit among ferrets but showed compromised fitness in vivo while in competition with the wild-type virus.
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Transmission of SARS-CoV-2 (Variant Delta) from Pet Hamsters to Humans and Onward Human Propagation of the Adapted Strain: A Case Study
Hui-Ling Yen,Thomas H. C. Sit,Christopher J. Brackman,Shirley S Y Chuk,Samuel M.S. Cheng,Haogao Gu,L. Chang,Pavithra Krishnan,Daisy Y M Ng,G. Liu,Ma Hui,Sin Ying Ho,Karina W. S. Tam,Pierra Y. T. Law,Wen Su,Sin Fun Sia,Ka-Tim Choy,S. Cheuk,Sylvia P. N. Lau,Amy W Y Tang,Joe Koo,Louise Yung,G Leung,J. S. Malik Peiris,Leo L.M. Poon +24 more
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