Metal complexes of Schiff bases synthesized from condensation of an amine with carbonyl compounds are widely used for industrial purposes such as catalysts, pigments and dyes, intermediates in orga...

REVIEW: Biomedical applications of Schiff base metal complexes

Synthesis, spectral characterization and antioxidant activity studies of a bidentate Schiff base, 5-methyl thiophene-2-carboxaldehyde-carbohydrazone and its Cd(II), Cu(II), Ni(II) and Zn(II) complexes.

Abstract The huge research on Schiff base coordination complexes in the past few decades has given rise to several new molecules that have been of biological importance. The ease with which the Schiff base ligands are designed and prepared and their pattern is elucidated have made them to be referred to as “fortunate ligands” possessing azomethine derivatives, the C=N linkage that is essential for biological activity, including antibacterial, antifungal, antioxidant, anticancer, and diuretic activities. A variety of Schiff base and its complexes have been studied as model molecules for biological oxygen carrier systems. The uses of Schiff bases as DNA-cleaving agents and its mode of interaction and free-radical scavenging properties are described. The review encapsulates the applications of Schiff bases and their complexes.

Transition metal complexes of symmetrical and asymmetrical Schiff bases as antibacterial, antifungal, antioxidant, and anticancer agents: progress and prospects

The primary processes in the photochemistry of Fe(III) complexes with carboxylic acids (glyoxalic, tartaric, pyruvic and lactic) were studied by means of laser flash photolysis. The inner-sphere electron transfer with the formation of Fe(II) complex and an escape of an organic radical to the solution bulk was shown to be a minor channel of the photolysis. The main channel was proposed to be the formation of a long-lived radical complex [FeII⋯˙OOC-R]2+. Spectral and kinetic parameters of the radical complexes are determined.

Intermediates in photochemistry of Fe(III) complexes with carboxylic acids in aqueous solutions

Preparation and identification of some metal complexes with new heterocyclic azo dye ligand 2-[2−- (1- Hydroxy -4- Chloro phenyl) azo ]- imidazole and their spectral and thermal studies

New Schiff bases have been synthesized from benzofuran-2-carbohydrazide and benzaldehyde,[BPMC] or 3,4-dimethoxybenzaldehyde, [BDMeOPMC]; complexes of the type $MLX_2$,where M=Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II), L=BPMC or BDMeOPMC and X = Cl, have been prepared. Structures have been elucidated on the basis of elemental analysis, conductance measurements, magnetic properties, spectral studies i.e., $^1H$ NMR, electronic, ESR and IR studies show that the Schiff bases are bidentate through the azomethine nitrogen and oxygen of the carbonyl. We propose tentative structures for all of these complexes. The antifungal and antibacterial activities of the ligands and their metal complexes have been screened against fungi Aspergillus niger and Aspergillus fumigatus and against bacteria Escherichia coli and S. aurious.

Synthesis, spectral characterization and biological activity of benzofuran Schiff bases with Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) complexes

Two Schiff-base ligands (I) naphthofuro-[phenylmethine]carbohydrazone [NPMC] and (II) naphthofruo-[3,4-dimethoxyphenylmethine]carbohydrazone [NDMeOPMC] were prepared by reaction between naphthofuran-2-carbohydrazone and benzaldehyde or 3,4-dihydroxybenzaldehyde, respectively. Both ligands are bidentate by coordinating through carboxy oxygen and azomethine nitrogen atoms. Complexes of the type MLX n were obtained. where M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II), UO2(II) and Th(IV), L = [NPMC] or [NDMeOPMC] and X = Cl2 for Co(II), Cu(II), Ni(II), Zn(II), Cd(II) and Hg(II) complexes, X = NO3, n = 2 for UO2(II) complexes and X = NO3, n = 4 for Th(IV) complexes. All the complexes and ligands were characterized IR, electronic, 1H NMR, ESR, conductance data and magnetic susceptibility measurements.

Synthesis and spectroscopic characterization of metal complexes with naphthofuran-2-carbohydrazide Schiff 's base

Complexes of the type $MLCl_2$, where M = Co(II), Cu(II), Ni(II), Zn(II), Cd(II) and Hg(II) and L is a thiosemicarbazide ligand derived from reaction between naphthofuran-2-carboxyhydrazide and p-chlorophenylisothiocynate (NCClPT)/p-bromophenylisothiocynate (NCBrPT) characterized by elemental analysis, conductance, magnetic susceptibility measurements, UV-Vis, IR, $^1HNMR$, and ESR. The thiosemicarbazide ligands are bidentate by coordinating through the oxygen of the carbonyl group and the nitrogen of the hydrazide residue. Based on the results, we propose structures for all the metal complexes. Both the ligands and their complexes have been screened for their fungicidal and bactericidal activities

Synthesis, characterization and antimicrobial studies on metal complexes with a naphthofuran thiosemicarbazide derivatives

The formation constants of 1: 1 and 1: 2 complexes between Co(II), Ni(II), Zn(II), Cd(II), Hg(II), Pb(II), Cu(II), Ba(II), Mg(II), Mn(II), Th(IV), and UO2 (II) metal ions and 2-phenyl-3-(2′-hydroxy-5′-methylbenzylidine)-quinazoline-4-(3H)-one [PHBMeQ] were determined potentiometrically at 30 ± 0.1 °C and different ionic strengths (0.025, 0.05, 0.10, 0.15, and 0.20 M NaNO3) in 60: 40 (v/v) alcohol-water solutions. The proton-ligand and metal-ligand formation constants were determined pH-metrically by the Calvin-Bjerrum titration technique. The order of stability constants was found. The negative ΔG° values suggest that the reactions occur spontaneously. Correlations between the log K1 values and some fundamental central metal ion properties are discussed.

The potentiometric and thermodynamic properties of some divalent metal ions with biologically active 2-phenyl-3-(2′-hydroxy-5′-methylbenzylidine)-quinazoline-4-(3h)-one Schiff’s base

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Synthesis, spectral characterization and biological activity of benzofuran Schiff bases with Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) complexes

Synthesis and spectroscopic characterization of metal complexes with naphthofuran-2-carbohydrazide Schiff 's base

Synthesis, characterization and antimicrobial studies on metal complexes with a naphthofuran thiosemicarbazide derivatives

The potentiometric and thermodynamic properties of some divalent metal ions with biologically active 2-phenyl-3-(2′-hydroxy-5′-methylbenzylidine)-quinazoline-4-(3h)-one Schiff’s base