K. Roger Aoki
Allergan
32 Papers
252 Citations
K. Roger Aoki is an academic researcher from Allergan. The author has contributed to research in topics: Biology & Epitope. The author has an hindex of 18, co-authored 32 publications.
Chat about Author
Papers
Selective inhibition of meningeal nociceptors by botulinum neurotoxin type A: Therapeutic implications for migraine and other pains
TL;DR: The findings suggest that BoNT-A interferes with neuronal surface expression of high-threshold mechanosensitive ion channels linked preferentially to mechanical pain by preventing their fusion into the nerve terminal membrane.
212
Plasma membrane localization signals in the light chain of botulinum neurotoxin.
Ester Fernandez-Salas,Lance E. Steward,Helen Ho,Patton E. Garay,Sarah W. Sun,Marcella A. Gilmore,Joseph V. Ordas,Joanne Wang,Joseph Francis,K. Roger Aoki +9 more
TL;DR: Using confocal microscopy and site-specific mutagenesis, this paper determined that the protease domain of BoNT/A light chain localizes in a punctate manner to the plasma membrane, colocalizing with the cleaved product, SNAP25197.
148
Novel Chimeras of Botulinum Neurotoxins A and E Unveil Contributions from the Binding, Translocation, and Protease Domains to Their Functional Characteristics
Jiafu Wang,Jianghui Meng,Gary W. Lawrence,Tomas H. Zurawski,Astrid Sasse,MacDara Bodeker,Marcella A. Gilmore,Ester Fernandez-Salas,Joseph Francis,Lance E. Steward,K. Roger Aoki,J. Oliver Dolly +11 more
TL;DR: Proof of principle is provided for tailoring the pharmacological properties of these toxins by protein engineering.
121
Intramuscular injection of 125I-botulinum neurotoxin-complex versus 125I-botulinum-free neurotoxin: time course of tissue distribution.
Diane D.-S. Tang-Liu,K. Roger Aoki,J. Oliver Dolly,Anton de Paiva,Tara L Houchen,Leslie F Chasseaud,Colin Webber +6 more
TL;DR: The results indicate that most of the neurotoxin does not diffuse from the injection site, whether in free or complexed form, and this may reduce the potential for systemic effects.
101
Mapping of the regions on the heavy chain of botulinum neurotoxin A (BoNT/A) recognized by antibodies of cervical dystonia patients with immunoresistance to BoNT/A.
TL;DR: The finding that the binding profile was not the same for all the patients is consistent with previous observations that immune responses to protein antigens are under genetic control and that the response to each epitope within a protein is under separate genetic control.
72