K.R. Walker
University of Western Australia
7 Papers
75 Citations
K.R. Walker is an academic researcher from University of Western Australia. The author has contributed to research in topics: Glycogen phosphorylase & Skeletal muscle. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of K.R. Walker include Murdoch University.
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Papers
Adenovirus and adeno-associated virus-mediated delivery of human myophosphorylase cDNA and LacZ cDNA to muscle in the ovine model of McArdle’s disease: Expression and re-expression of glycogen phosphorylase
J.Mc.C. Howell,J.Mc.C. Howell,K.R. Walker,L. Davies,E. Dunton,A. Everaardt,Nigel G. Laing,George Karpati +7 more
TL;DR: The results presented here suggest that the use of viral vector-mediated phosphorylase gene transfer may be applicable to the treatment of McArdle's disease and that sustained re-expression of the brain and liver isoforms should also be investigated as a possible treatment.
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Phosphorylase re-expression, increase in the force of contraction and decreased fatigue following notexin-induced muscle damage and regeneration in the ovine model of McArdle disease
J.Mc.C. Howell,J.Mc.C. Howell,K.R. Walker,K. E. Creed,E. Dunton,L. Davies,Ros Quinlivan,George Karpati +7 more
TL;DR: The sustained re-expression of both the brain and liver isoforms of phosphorylase within the muscle fibres provides further emphasis that strategies to enhance the re- expression of these isoforms should be investigated as a possible treatment for McArdle disease.
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Production of human skeletal α-actin proteins by the baculovirus expression system
P. Anthony Akkari,Kristen J. Nowak,Kaye Beckman,K.R. Walker,K.R. Walker,Fred Schachat,Nigel G. Laing +6 more
TL;DR: It is shown that non-mutated actin produced in the BEVS behaves similarly to native actin, as shown by DNase I affinity purification, Western blotting, and consecutive cycles of polymerisation and depolymerisation.
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Expression of cardiac α-actin spares extraocular muscles in skeletal muscle α-actin diseases – Quantification of striated α-actins by MRM-mass spectrometry
Gianina Ravenscroft,Stephen M.J. Colley,Stephen M.J. Colley,K.R. Walker,Sophie Clément,Scott Bringans,Richard J. Lipscombe,Victoria A. Fabian,Nigel G. Laing,Kristen J. Nowak +9 more
TL;DR: By immunochemistry, Western blotting and a novel MRM-mass spectrometry technique, comparable levels of cardiac alpha-actin are shown in the extraocular muscles of human, pig and sheep to those in the heart.
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Phosphorylase re-expression, increase in the force of contraction and decreased fatigue following notexin-induced muscle damage and regeneration in the ovine model of McArdle disease
J.Mc.C. Howell,J.Mc.C. Howell,K.R. Walker,K. E. Creed,E. Dunton,L. Davies,Ros Quinlivan,George Karpati +7 more
- 01 Jan 2013
TL;DR: In this paper, the injection of notexin into, or the layering of non-muscle isoforms of myophosphorylase onto, the muscles of affected sheep resulted in necrosis followed by regeneration of muscle fibres with the expression of both nonmuscle and liver isoforms within the fibres and a reduction of the amount of glycogen in the muscle with an increase in the strength of contraction and a decrease in fatiguability.
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