K. N. Houk
University of California, Los Angeles
7 Papers
90 Citations
K. N. Houk is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Catalysis & Chemistry. The author has an hindex of 4, co-authored 7 publications. Previous affiliations of K. N. Houk include Université catholique de Louvain.
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Papers
Mechanism and transition-state structures for nickel-catalyzed reductive alkyne-aldehyde coupling reactions.
TL;DR: In this article, the rate and selectivity-determining oxidative cyclization transition state is analyzed in detail and the d → π*⊥ back-donation stabilizes the transition state and leads to higher reactivity for alkynes than alkenes.
Generation and Regioselective Trapping of a 3,4-Piperidyne for the Synthesis of Functionalized Heterocycles
TL;DR: The generation of the first 3,4-piperidyne is reported and its use as a building block for the synthesis of annulated piperidines and the distortion/interaction model is used to explain the observed regioselectivities.
Mechanism and Transition-State Structures for Nickel-Catalyzed Reductive Alkyne−Aldehyde Coupling Reactions
Patrick McCarren,Peng Liu,Paul Ha-Yeon Cheong,Timothy F. Jamison,K. N. Houk +4 more
- 01 Apr 2009
TL;DR: The mechanism of nickel-catalyzed reductive alkyne-aldehyde coupling reactions has been investigated using density functional theory and the rate- and selectivity-determining oxidative cyclization transition state is analyzed in detail.
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Suzuki—Miyaura Cross-Coupling of Aryl Carbamates and Sulfamates: Experimental and Computational Studies.
Kyle W. Quasdorf,Aurora Antoft-Finch,Peng Liu,Amanda L. Silberstein,Anna Komaromi,Tom Blackburn,Stephen D. Ramgren,K. N. Houk,Victor Snieckus,Neil K. Garg +9 more
TL;DR: The cross-coupling uses the inexpensive, bench-stable catalyst NiCl2(PCy3)2 to deliver biaryls in good to excellent yield.
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Generation and Regioselective Trapping of a 3,4‐Piperidyne for the Synthesis of Functionalized Heterocycles.
TL;DR: The first 3,4-piperidyne was reported in this article, and its use as a building block for the synthesis of annulated piperidines was described.
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