Ecotoxicological effects of selected cyanobacterial secondary metabolites: a short review.

Alzheimer's disease (AD) is a progressive, neurodegenerative pathology that primarily affects the elderly population, and is estimated to account for 50-60% of dementia cases in persons over 65 years of age. The main symptoms associated with AD involve cognitive dysfunction, primarily memory loss. Other features associated with the later stages of AD include language deficits, depression, behavioural problems including agitation, mood disturbances and psychosis. One of the most promising approaches for treating this disease is to enhance the acetylcholine level in the brain using acetylcholinesterase (AChE) inhibitors. The present work reviews the literature on plants and plant-derived compounds inhibitors of enzyme acetylcholinesterase. The review refers to 309 plant extracts and 260 compounds isolated from plants, which are classified in appropriate chemical groups and model tested, and cites their activity. For this purpose 175 references were consulted.

/pdf/natural-products-inhibitors-of-the-enzyme-14imhrjo4b.pdf

Natural products inhibitors of the enzyme acetylcholinesterase

The phylum Mollusca represents an enormous diversity of species with eight distinct classes. This review provides a taxonomic breakdown of the published research on marine molluscan natural products and the medicinal products currently derived from molluscs, in order to identify priority targets and strategies for future research. Some marine gastropods and bivalves have been of great interest to natural products chemists, yielding a diversity of chemical classes and several drug leads currently in clinical trials. Molluscs also feature prominently in a broad range of traditional natural medicines, although the active ingredients in the taxa involved are typically unknown. Overall secondary metabolites have only been investigated from a tiny proportion (<1%) of molluscan species. At the class level, the number of species subject to chemical studies mirrors species richness and our relative knowledge of the biology of different taxa. The majority of molluscan natural products research is focused within one of the major groups of gastropods, the opisthobranchs (a subgroup of Heterobranchia), which are primarily comprised of soft-bodied marine molluscs. Conversely, most molluscan medicines are derived from shelled gastropods and bivalves. The complete disregard for several minor classes of molluscs is unjustified based on their evolutionary history and unique life styles, which may have led to novel pathways for secondary metabolism. The Polyplacophora, in particular, have been identified as worthy of future investigation given their use in traditional South African medicines and their abundance in littoral ecosystems. As bioactive compounds are not always constitutively expressed in molluscs, future research should be targeted towards biosynthetic organs and inducible defence reactions for specific medicinal applications. Given the lack of an acquired immune system, the use of bioactive secondary metabolites is likely to be ubiquitous throughout the Mollusca and broadening the search field may uncover interesting novel chemistry.

https://tekhelet.com/pdf/Benkendorff-Biological-2010.pdf

Molluscan biological and chemical diversity: secondary metabolites and medicinal resources produced by marine molluscs.

Indole alkaloids from Tabernaemontana australis (Muell. Arg) Miers that inhibit acetylcholinesterase enzyme.

Recent progress in the chemistry of the monoterpenoid indole alkaloids

An investigation of the indole alkaloids of Haplophyton crooksii has resulted in the identification of two new alkaloids10-methoxy-N1-methylpericyclivine (1) and 16-decarbomethoxyvinervinine (2)and 13 known alkaloidscrooksiine, yohimbine, β-yohimbine, crooksidine, decarbomethoxytetrahydrosecodine, akuammicine, tubotaiwine, lanceomigine, lanceomigine N-oxide, haplophytine, cimicine, cimicidine, and akuammidinas major alkaloids of this shrub. All of the isolated alkaloids showed an inhibition of acetylcholinesterase activity in vitro.

Indole alkaloids of Haplophyton crooksii

Unusual occurrence of fulvoplumierin, an antibacterial pigment, in the marine mollusk Nerita albicilla

Constituents of Couepia paraensis.

Isolation and crystal structure of 5-hydroxy-2,8-dimethyl-6,7-dimethoxybenzopyran-4-one from Couepia paraensis

Natural blooms of the blue-green alga Aphanizomenon flos-aquae occur periodically in the lakes of the northern United States and in certain provinces of Canada. These blooms have been reported to cause poisoning in fish and cattle. Investigation of the toxins of A. flos-aquae indicates that this alga contains three toxins in addition to saxitoxin. The aphantoxins appear to have a chemical structure similar to saxitoxin.

Chemical Studies on Toxins from the Blue-Green Alga Aphanizomenon Flos-Aquae

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

K. L. Euler

Author Tools

Chat about Author