K. L. Cheever
Harvard University
5 Papers
102 Citations
K. L. Cheever is an academic researcher from Harvard University. The author has contributed to research in topics: Paraoxon & Malathion. The author has an hindex of 5, co-authored 5 publications.
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Papers
Comparative toxicity, anticholinesterase action and metabolism of methyl parathion and parathion in sunfish and mice.
TL;DR: In mice the GSH-dependent enzymes also favored detoxification of methyl parathion and methyl paraoxon, but this is apparently of less importance because of their high cholinesterase sensitivity and because cleavage and hydrolysis favored parathions and paraox on.
170
Comparative anticholinesterase action of organophosphorus insecticides in vertebrates.
TL;DR: The results of this investigation indicate that for some compounds species differences in the sensitivities of the cholinesterases to inhibition are sufficiently large to modify the influence of differences in rates of metabolism.
82
Carboxylesterase and cholinesterase inhibition in rats. Abate and interaction with malathion.
Sheldon D. Murphy,K. L. Cheever +1 more
TL;DR: Hydrolysis of diethyl succinate, methyl butyrate, and triacetin by rat liver carboxylesterases was inhibited in vivo and in vitro by the insecticide, Abate, which increased rat susceptibility to the anticholinesterase action of a single 400-mg/kg dose of malathion, which is detoxified by carboxyleterases.
14
A comparison of gas chromatographic and anti-cholinesterase methods for measuring parathion metabolism in vitro.
TL;DR: The purpose of this study was to adapt a gas chromatographic procedure suitable for routine determinations of small amounts of paraoxon produced in tissue incubations in the presence of a large excess of parathion as substrate to compare its utility with that of the anti-cholinesterase method of assaying for paraox on.
8
Effect of feeding insecticides. Inhibition of carboxyesterase and cholinesterase activities in rats.
Sheldon D. Murphy,K. L. Cheever +1 more
TL;DR: Red blood cell cholinesterase was equally as sensitive as liver and plasma carboxyesterase to Inhibition by low dietary concentrations of parathion, however, rats that were fed concentrations of dioxathion or ronnel were more susceptible to brain cholinersterase Inhibition following a single dose of malathion.