22 Papers
223 Citations
K. Kemp is an academic researcher from Copenhagen University Hospital. The author has contributed to research in topics: Cytokine & Antigen. The author has an hindex of 14, co-authored 22 publications. Previous affiliations of K. Kemp include University of Copenhagen.
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Papers
T-cell response in human leishmaniasis.
Arsalan Kharazmi,K. Kemp,A. Ismail,S. Gasim,A. Gaafar,Jørgen A. L. Kurtzhals,A.M. El Hassan,Thor G. Theander,Michael Kemp +8 more
TL;DR: Evidence is provided for the existence of a Th1/Th2 dichotomy in the T-cell response to Leishmania antigens in human leishmaniasis and the data suggest that the pattern of IL-4 and IFN-gamma response is polarised in these patients.
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Leishmania‐specific T cells expressing interferon‐gamma (IFN‐γ) and IL‐10 upon activation are expanded in individuals cured of visceral leishmaniasis
K. Kemp,Michael Kemp,A Kharazmi,A Kharazmi,Azzam Ismail,Jørgen A. L. Kurtzhals,Lars Hviid,Thor G. Theander +7 more
TL;DR: Peripheral blood mononuclear cells from patients who have recovered from visceral leishmaniasis often respond to Leishmania antigens in vitro by production of both IL‐4, IFN‐γ and IL‐10, and these cells were identified as a regulatory subset of T cells important for maintaining a balance between Th1‐ and Th2‐type cells in these individuals.
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Immunopathology of post kala-azar dermal leishmaniasis (PKDL): T-cell phenotypes and cytokine profile.
A. Ismail,A.M. El Hassan,K. Kemp,S. Gasim,A E Kadaru,Torsten Møller,Arsalan Kharazmi,Thor G. Theander +7 more
TL;DR: The results indicate that PKDL develops as a result of an influx of immunocompetent cells into skin, which harbours parasites, and the inflammatory response to the parasites is complex.
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Pneumococcal infections in humans are associated with increased apoptosis and trafficking of type 1 cytokine-producing T cells.
TL;DR: Data suggest that activated T lymphocytes with a type 1 cytokine profile are highly engaged in the in vivo immune response to S. pneumoniae, suggesting the underlying mechanisms during infection may include sequestration in the peripheral tissues and/or apoptosis.
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Cytokine production and apoptosis among T cells from patients under treatment for Plasmodium falciparum malaria
K. Kemp,Bartholomew D. Akanmori,Victoria Adabayeri,Bamenla Q. Goka,Jørgen A. L. Kurtzhals,Jørgen A. L. Kurtzhals,Jørgen A. L. Kurtzhals,Charlotte Behr,Lars Hviid +8 more
TL;DR: The cytokine production capacity and susceptibility to programmed cell death of peripheral T cells during and after the period of antimalarial treatment are examined, consistent with the concept of malaria‐induced reallocation of activated T cells to sites of inflammation, followed by their release back into the peripheral blood where they undergo apoptotic death to re‐establish immunological homeostasis as inflammation subsides.
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