K-John Cheung
BC Cancer Agency
15 Papers
102 Citations
K-John Cheung is an academic researcher from BC Cancer Agency. The author has contributed to research in topics: Comparative genomic hybridization & Apoptosis. The author has an hindex of 11, co-authored 15 publications. Previous affiliations of K-John Cheung include University of British Columbia & Vancouver Hospital and Health Sciences Centre.
Chat about Author
Papers
Acquired TNFRSF14 Mutations in Follicular Lymphoma Are Associated with Worse Prognosis
K-John Cheung,Nathalie A. Johnson,Joslynn G. Affleck,Tesa M. Severson,Christian Steidl,Susana Ben-Neriah,Jacqueline E. Schein,Ryan D. Morin,Richard D. Moore,Sohrab P. Shah,Hong Qian,Jessica E. Paul,Adele Telenius,Thomas Relander,Wan L. Lam,Kerry J. Savage,Joseph M. Connors,Carolyn J. Brown,Marco A. Marra,Randy D. Gascoyne,Douglas E. Horsman +20 more
TL;DR: TNFRSF14 is identified as a candidate gene associated with a subset of FL, based on frequent occurrence of acquired mutations and their correlation with inferior clinical outcomes, and its association with inferior OS and DSS is identified.
186
•Journal Article
The Tumor Suppressor Candidate p33ING1 Mediates Repair of UV-Damaged DNA
TL;DR: It is found that overexpression of p33(ING1) enhances repair of UV-damaged DNA and that p53 is required for the repair process, and binding between ING1 and GADD45 has been detected, suggesting that p 33(ING 1) cooperates with p53 in nucleotide excision repair and that Gadd45 may be one of its components.
124
The significance of TP53 in lymphoid malignancies: mutation prevalence, regulation, prognostic impact and potential as a therapeutic target.
TL;DR: The prevalence of TP53 aberrations and their prognostic significance in various types of lymphoid cancer and the use of recent therapeutic modalities that target TP53 are examined.
65
The tumor suppressor ING1: structure and function.
K-John Cheung,Gang Li +1 more
TL;DR: The biological functions of the tumor suppressor ING1 have been studied extensively in the past 5 years since it was cloned and the cloning errors originating from the isolation of this gene are clarified.
44
Tissue-specific regulation of Fas/APO-1/CD95 expression by p53.
TL;DR: Using the p53 knockout mouse model, it is demonstrated that Fas expression is reduced in spleen and liver from p53-/- mice compared to p53+/+ controls, while similar expression levels were observed in brain, heart, kidney, lung, skin, testis, and thymus between the two groups.
25