K Henshaw
University of Leeds
17 Papers
4 Citations
K Henshaw is an academic researcher from University of Leeds. The author has contributed to research in topics: Mesenchymal stem cell & Rituximab. The author has an hindex of 13, co-authored 17 publications. Previous affiliations of K Henshaw include National Institute for Health Research.
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Papers
Enumeration and phenotypic characterization of synovial fluid multipotential mesenchymal progenitor cells in inflammatory and degenerative arthritis
Elena Jones,Anne English,K Henshaw,Sally E. Kinsey,Alex F. Markham,Paul Emery,Dennis McGonagle +6 more
TL;DR: The findings prove the presence of rare tripotential MPCs, at the single-cell level, in the SF of patients with arthritis, and could determine the role of MPCs in the pathogenesis of inflammatory arthritis, together with their role in attempted joint regeneration in degenerative arthritis, which has yet to be established.
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B cell biomarkers of rituximab responses in systemic lupus erythematosus.
Edward M Vital,Shouvik Dass,Maya H Buch,K Henshaw,Colin T. Pease,Michael F. Martin,Frederique Ponchel,Andy C. Rawstron,Paul Emery +8 more
TL;DR: Findings indicate that rituximab is effective in SLE, and clinical responses are supported by close correlation with B cell numbers, and HSFC is a valuable tool in the assessment and prediction of response in Sle.
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Vertebral body versus iliac crest bone marrow as a source of multipotential stromal cells: Comparison of processing techniques, tri-lineage differentiation and application on a scaffold for spine fusion.
Evangelos M. Fragkakis,Jehan J. El-Jawhari,Jehan J. El-Jawhari,Robert Dunsmuir,Peter Millner,Abhay Rao,K Henshaw,Ippokratis Pountos,Elena Jones,Peter V. Giannoudis,Peter V. Giannoudis +10 more
TL;DR: VB-BM MSCs have a comparable phenotype and proliferative capacity, but higher chondrogenesis and osteogenesis with or without using scaffold than donor-matched IC-BMMSCs, and given better accessibility, VB- BM could be an ideal MSC source for spinal bone fusion.
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Release of growth factors and the effect of age, sex, and severity of injury after long bone fracture. A preliminary report.
TL;DR: This study analyzed the kinetics of key growth factors following lower-limb long bone fracture and found that there was a decline in the levels of PDGF-BB, IGF-I and TGF-β1 during the first 3 days after fracture, but by 7 days postoperatively, the levels had increased considerably.
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Association between clinical response and CIRCULATING B cell subsets during B cell depletion therapy for systemic lupus erythematosus
E.M. Vital,Shouvik Dass,Maya H Buch,K Henshaw,Andy C. Rawstron,Frederique Ponchel,Paul Emery +6 more
TL;DR: In this series, reduction ofAutoantibody titre was greater when plasmablast numbers were undetectable after rituximab, but normalisation of autoantibodies titre did not appear to be required for good clinical response.
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