7 Papers
9 Citations
K. Harini is an academic researcher from National Centre for Biological Sciences. The author has contributed to research in topics: Docking (molecular) & Virtual screening. The author has an hindex of 4, co-authored 6 publications.
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Papers
Genome sequencing of herb Tulsi (Ocimum tenuiflorum) unravels key genes behind its strong medicinal properties.
Atul Kumar Upadhyay,Anita Chacko,A. Gandhimathi,Pritha Ghosh,K. Harini,Agnel Praveen Joseph,Adwait G. Joshi,Adwait G. Joshi,Snehal D. Karpe,Swati Kaushik,Nagesh A. Kuravadi,Chandana Shankara Lingu,Jarjapu Mahita,Ramya Malarini,Sony Malhotra,Manoharan Malini,Oommen K. Mathew,Oommen K. Mathew,Eshita Mutt,Mahantesha B.N. Naika,Sathyanarayanan Nitish,Shaik Naseer Pasha,Shaik Naseer Pasha,Upadhyayula S. Raghavender,Anantharamanan Rajamani,S Shilpa,Prashant Shingate,Prashant Shingate,Heikham Russiachand Singh,Anshul Sukhwal,Anshul Sukhwal,Margaret S. Sunitha,Manojkumar Sumathi,S. Ramaswamy,Malali Gowda,Ramanathan Sowdhamini +35 more
TL;DR: The availability of the whole genome of O.tenuiflorum and the sequence analysis suggests that small amino acid changes at the functional sites of genes involved in metabolite synthesis pathways confer special medicinal properties to this herb.
The transcriptome enables the identification of candidate genes behind medicinal value of Drumstick tree (Moringa oleifera).
Shaik Naseer Pasha,K. Mohamed Shafi,Adwait G. Joshi,Iyer Meenakshi,K. Harini,Jarjapu Mahita,Radha Sivarajan Sajeevan,Snehal D. Karpe,Pritha Ghosh,Sathyanarayanan Nitish,A. Gandhimathi,Oommen K. Mathew,Subramanian Hari Prasanna,Manoharan Malini,Eshita Mutt,Mahantesha B.N. Naika,Nithin Ravooru,Rajas M. Rao,Prashant Shingate,Anshul Sukhwal,Margaret S. Sunitha,Atul Kumar Upadhyay,Rithvik S. Vinekar,Ramanathan Sowdhamini +23 more
TL;DR: A bioinformatics pipeline was developed to assemble transcriptome, along with the previously published M. oleifera genome, to predict 17,148 gene models and few candidate genes related to biosynthesis of secondary metabolites, vitamins and ion transporters were identified.
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Computational Approaches for Decoding Select Odorant-Olfactory Receptor Interactions Using Mini-Virtual Screening.
K. Harini,Ramanathan Sowdhamini +1 more
TL;DR: This study revealed that homologous sequences with high sequence identity need not bind to the same/ similar ligand with a given affinity, which will be useful for expression and mutation studies on these receptors.
Exploring the medicinally important secondary metabolites landscape through the lens of transcriptome data in fenugreek (Trigonella foenum graecum L.)
Mahantesha B.N. Naika,Nitish Sathyanarayanan,Radha Sivarajan Sajeevan,Teerna Bhattacharyya,Pritha Ghosh,Meenakshi S Iyer,Mahita Jarjapu,Adwait G. Joshi,K. Harini,K. Mohamed Shafi,Neha V. Kalmankar,Snehal D. Karpe,Bhavika Mam,Shaik Naseer Pasha,Ramanathan Sowdhamini +14 more
TL;DR: In this paper , the authors performed a combined transcriptome assembly from RNA sequencing data derived from leaf, stem and root tissues and reported transcripts that bear sequence signatures of enzymes involved in the biosynthesis of such metabolites and are highly expressed in leaves, stem, and roots.
An in silico approach towards the identification of novel inhibitors of the TLR-4 signaling pathway.
TL;DR: Virtual screening of commercially available small molecules targeting the binding site enabled to short-list 12 small molecules to abrogate TRAM-mediated TLR4 signaling.
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