K. Freeman
11 Papers
K. Freeman is an academic researcher. The author has contributed to research in topics: Medicine & Bacteriophage. The author has an hindex of 4, co-authored 6 publications.
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Papers
Phage Therapy of Mycobacterium Infections: Compassionate Use of Phages in 20 Patients With Drug-Resistant Mycobacterial Disease
Rebekah M. Dedrick,Bailey E. Smith,Madison Cristinziano,K. Freeman,Deborah Jacobs-Sera,Yvonne Belessis,A. Whitney Brown,Keira A. Cohen,Rebecca M. Davidson,David van Duin,Andrew B Gainey,Cristina Berastegui Garcia,C. R. Robert George,Ghady Haidar,Winnie Ip,Jonathan R. Iredell,Ameneh Khatami,Jessica S. Little,Kirsi Malmivaara,Brendan McMullan,David E. Michalik,Andrea Moscatelli,Jerry A. Nick,Maria Gabriela Tupayachi Ortiz,Hari Polenakovik,Paul Robinson,Mikael Skurnik,Daniel Solomon,James Soothill,Helen Spencer,Peter A. B. Wark,Austen Worth,Robert T. Schooley,Constance A. Benson,Graham F. Hatfull +34 more
TL;DR: Phage treatment of Mycobacterium infections is challenging due to the limited repertoire of therapeutically useful phages, but favorable clinical outcomes in patients lacking any other treatment options support continued development of adjunctive phage therapy for some mycobacterial infections.
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Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection
Jerry A. Nick,Rebekah M. Dedrick,Alice L. Gray,E. Vladar,Bailey E. Smith,K. Freeman,Kenneth C. Malcolm,L. Elaine Epperson,Nabeeh A. Hasan,Jordi Hendrix,Kimberly Callahan,Kendra N. Walton,Brian Vestal,Emily C. Wheeler,Noel Rysavy,Katie R. Poch,Silvia M. Caceres,V. Lovell,Katherine B. Hisert,Vinicius Calado Nogueira de Moura,Delphi Chatterjee,Prithwiraj De,Natalia Weakly,Stacey L. Martiniano,David A. Lynch,Charles L. Daley,Michael J. Strong,F. Jia,Graham F. Hatfull,Rebecca M. Davidson +29 more
TL;DR: The course and associated markers of a successful phage treatment of M. abscessus in advanced lung disease are described and evidence of phage-induced lysis was observed using molecular and metabolic assays combined with clinical assessments.
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Bacteriophage treatment of disseminated cutaneous Mycobacterium chelonae infection
Jessica S. Little,Rebekah M. Dedrick,K. Freeman,Madison Cristinziano,Bailey E. Smith,Constance A. Benson,Tulip Jhaveri,Lindsey R. Baden,Daniel Solomon,Graham F. Hatfull +9 more
TL;DR: A case of refractory cutaneous disseminated M. chelonae infection in a patient with seronegative arthritis on immunotherapy with tofacitinib that was treated with combination antimicrobial, surgical, and single bacteriophage therapy with excellent clinical response was reported in this paper .
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Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease
Rebekah M. Dedrick,K. Freeman,Jan A. Nguyen,Asli Bahadirli-Talbott,M. Cardin,Madison Cristinziano,Bailey E. Smith,Soo Jeong Jeong,Elisa Ignatius,Cheng Ting Lin,Keira A. Cohen,Graham F. Hatfull +11 more
TL;DR: An elderly man with refractory Mycobacterium abscessus lung disease previously developed anti-phage neutralizing antibodies while receiving intravenous phage therapy, and subsequent phage nebulization resulted in transient weight gain, decreased C-reactive protein, and reduced Myc Cobacterium burden.
Virion glycosylation influences mycobacteriophage immune recognition.
K. Freeman,Anna Robotham,Olivia B. Parks,Lawrence Abad,Deborah Jacobs-Sera,Jennifer M. Podgorski,John D. Williams,Simon J. White,John F. Kelly,Graham F. Hatfull,Welkin H. Pope +10 more
TL;DR: In this article , it was shown that several genomically distinct phages of Mycobacteria are modified with glycans attached to the C terminus of capsid and tail tube protein subunits.
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