K Deutschmann
University of Düsseldorf
11 Papers
50 Citations
K Deutschmann is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: G protein-coupled bile acid receptor & Farnesoid X receptor. The author has an hindex of 6, co-authored 11 publications.
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Papers
TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro
M Reich,K Deutschmann,Annika Sommerfeld,Caroline Klindt,Stefanie Kluge,Ralf Kubitz,Christoph Ullmer,Wolfram T. Knoefel,Diran Herebian,Ertan Mayatepek,Dieter Häussinger,Verena Keitel +11 more
TL;DR: These mechanisms may protect cholangiocytes from BA toxicity under cholestatic conditions, however, they may trigger proliferation and apoptosis resistance in malignantly transformed cholangsiocytes, thus promoting CCA progression.
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Bile acid receptors in the biliary tree: TGR5 in physiology and disease.
K Deutschmann,M Reich,Caroline Klindt,Carola Dröge,Lina Spomer,Dieter Häussinger,Verena Keitel +6 more
TL;DR: TGR5 overexpression or constant stimulation of the receptor can promote cholangiocyte proliferation leading to cyst growth in polycystic liver disease or even progression of cholangsiocarcinoma, which represents potential therapeutic approaches for different types of biliary diseases.
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The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium
Christoph Gerhardt,Johanna Maria Lier,Stephan Burmühl,Andreas Struchtrup,K Deutschmann,Maik Vetter,Tristan Leu,Sandra Reeg,Tilman Grune,Ulrich Rüther +9 more
TL;DR: Rpgrip1l regulates proteasomal activity at the basal body via Psmd2 and thereby controls ciliary signaling.
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Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis.
M Reich,Lina Spomer,Caroline Klindt,Katharina Fuchs,Jan Stindt,K Deutschmann,Johanna Höhne,Evaggelia Liaskou,Evaggelia Liaskou,Johannes R. Hov,Johannes R. Hov,Tom H. Karlsen,Tom H. Karlsen,Ulrich Beuers,Joanne Verheij,Sofia Ferreira-Gonzalez,Gideon M. Hirschfield,Stuart J. Forbes,Christoph Schramm,Irene Esposito,Dirk Nierhoff,Peter Fickert,Claudia D. Fuchs,Michael Trauner,María García-Beccaria,Gisela Gabernet,Sven Nahnsen,Jan-Philipp Mallm,Marina Vogel,Kristina Schoonjans,Tobias Lautwein,Karl Köhrer,Dieter Häussinger,Tom Luedde,Mathias Heikenwalder,Verena Keitel +35 more
TL;DR: In this paper, the effects of IL8/IL8 homologues on bile acid receptor TGR5 mRNA and protein levels in Bile epithelial cells (BECs) were studied.
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The Epidermal Growth Factor Receptor Ligand Amphiregulin Protects From Cholestatic Liver Injury and Regulates Bile Acids Synthesis
Eva Santamaría,Eva Santamaría,C.M. Rodriguez-Ortigosa,C.M. Rodriguez-Ortigosa,Iker Uriarte,Iker Uriarte,Maria U. Latasa,Raquel Urtasun,Gloria Alvarez-Sola,Marina Bárcena-Varela,Leticia Colyn,Sara Arcelus,Maddalen Jimenez,K Deutschmann,Ana Peleteiro-Vigil,Julian Gomez-Cambronero,Malgorzata Milkiewicz,Piotr Milkiewicz,Piotr Milkiewicz,Bruno Sangro,Verena Keitel,Maria J. Monte,Maria J. Monte,Jose J.G. Marin,Jose J.G. Marin,Maite G. Fernandez-Barrena,Maite G. Fernandez-Barrena,Matías A. Avila,Matías A. Avila,Carmen Berasain,Carmen Berasain +30 more
TL;DR: It is shown that hepatic EGFR expression is indirectly induced by BA‐FXR through activation of suppressor of cytokine signaling‐3 (SOC3) and participates in the physiological regulation of BA synthesis.
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