K. de Silva
University of Sydney
9 Papers
27 Citations
K. de Silva is an academic researcher from University of Sydney. The author has contributed to research in topics: Mycobacterium avium subspecies paratuberculosis & Paratuberculosis. The author has an hindex of 6, co-authored 9 publications.
Chat about Author
Papers
Case definition terminology for paratuberculosis (Johne's disease).
Richard Whittington,Douglas J. Begg,K. de Silva,Auriol C. Purdie,Navneet K. Dhand,Karren M. Plain +5 more
TL;DR: Descriptive terms for different stages in the pathogenesis of paratuberculosis are proposed to enable their use in different types of studies and to enable an independent assessment of the extent to which accepted definitions for stages of disease have been applied consistently in any given study.
Applying the One Health Concept to Mycobacterial Research - Overcoming Parochialism.
S. Thirunavukkarasu,S. Thirunavukkarasu,Karren M. Plain,K. de Silva,Ben J. Marais,Richard Whittington +5 more
TL;DR: In this article, a comprehensive review of the zoonotic aspect of mycobacteria in the context of the One Health initiative is provided, with the purpose of providing a concise and comprehensive resource.
24
Specific faecal antibody responses in sheep infected with Mycobacterium avium subspecies paratuberculosis.
Douglas J. Begg,K. de Silva,Karren M. Plain,Auriol C. Purdie,Navneet K. Dhand,Richard Whittington +5 more
TL;DR: It is hypothesised that the survivors produced faecal Ig as a direct response to ingestion of MAP associated with environmental contamination from clinical cases may play a previously unreported role as part of a protective response triggered by environmental exposure.
16
The immunogenicity and tissue reactivity of Mycobacterium avium subsp paratuberculosis inactivated whole cell vaccine is dependent on the adjuvant used
Douglas J. Begg,Om P. Dhungyel,A. Naddi,Navneet K. Dhand,Karren M. Plain,K. de Silva,Auriol C. Purdie,Richard Whittington +7 more
TL;DR: It may be possible to uncouple protective immunity from excessive tissue reactivity, and apparently poorly immunogenic antigens may be re-examined to determine if an appropriate immune profile can be established using different adjuvants.
13
Identification of differentially expressed genes in ileum, intestinal lymph node and peripheral blood mononuclear cells of sheep infected with Mycobacterium avium subsp. paratuberculosis using differential display polymerase chain reaction.
TL;DR: Genes identified in association with M. ptb infection had a wide range of functions in pathways including: antigen presentation, signal transduction and cell differentiation, TLR signaling, immune cell activation and chemokine functions, granulomatous inflammation, Th1 suppression and apoptosis.
12