Justin R. Nodwell
University of Toronto
74 Papers
800 Citations
Justin R. Nodwell is an academic researcher from University of Toronto. The author has contributed to research in topics: Streptomyces coelicolor & Streptomyces. The author has an hindex of 32, co-authored 65 publications. Previous affiliations of Justin R. Nodwell include McMaster University & Harvard University.
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Papers
Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1.
Nancy L. McKenzie,Maulik N. Thaker,Kalinka Koteva,Donald W. Hughes,Gerard D. Wright,Justin R. Nodwell +5 more
TL;DR: A pleiotropic regulator of secondary metabolism from Streptomyces coelicolor is used to activate secondary biosynthetic gene clusters in heterologous streptomycetes, and new, broad-spectrum antimicrobial activities for pulvomycin are identified.
An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris
Kali R. Iyer,Kaddy Camara,Martin Daniel-Ivad,Richard Trilles,Sheila M. Pimentel-Elardo,Jen Fossen,Karen Marchillo,Zhongle Liu,Shakti Singh,José F. Muñoz,Sang Hu Kim,John A. Porco,Christina A. Cuomo,Noelle S. Williams,Ashraf S. Ibrahim,Ashraf S. Ibrahim,John E. Edwards,John E. Edwards,David R. Andes,Justin R. Nodwell,Lauren E. Brown,Luke Whitesell,Nicole Robbins,Leah E. Cowen +23 more
TL;DR: In this article, a bis-benzodioxolylindolinone (azoffluxin) was identified that synergizes with fluconazole against C. auris.
Ligand Recognition by ActR, a TetR-Like Regulator of Actinorhodin Export
TL;DR: The ligand-binding cavity of this protein can accommodate a surprisingly large diversity of ligands, many of which can release ActR from DNA in vitro and in vivo, suggesting that the actR locus could be activated by, and perhaps adapted to confer resistance to other antibiotics.
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Structural and Genetic Analysis of the BldB Protein of Streptomyces coelicolor
TL;DR: It is demonstrated that the bldB gene of Streptomyces coelicolor is required for the formation of aerial hyphae and the synthesis of antibiotics and that amino acid residues 20 to 78 are important for this interaction, suggesting that dimer formation may be a common feature of these proteins.
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Novel links between antibiotic resistance and antibiotic production.
TL;DR: Nishimura et al. as mentioned in this paper showed that the S. coelicolor genome encodes proteins that are similar in sequence and mechanism to those that confer clinical resistance to vancomycin.
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