Justin E. Piazza
McMaster University
5 Papers
5 Citations
Justin E. Piazza is an academic researcher from McMaster University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 4 publications.
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Papers
Haloperidol-loaded intranasally administered lectin functionalized poly(ethylene glycol)-block-poly(D,L)-lactic-co-glycolic acid (PEG-PLGA) nanoparticles for the treatment of schizophrenia.
Justin E. Piazza,Todd Hoare,Luke Molinaro,Kristen Terpstra,Jayant Bhandari,P. Ravi Selvaganapathy,Bhagwati P. Gupta,Ram K. Mishra +7 more
TL;DR: This formulation demonstrates promise in the reduction of the drug dose necessary to produce a therapeutic effect with antipsychotic drugs for the treatment of schizophrenia by demonstrating minimal drug leakage and the potential for the efficient drug transport to the targeted brain tissue.
92
Intranasal delivery of antipsychotic drugs.
Yogesh K. Katare,Justin E. Piazza,Jayant Bhandari,Ritesh Daya,Kosalan Akilan,Madeline J. Simpson,Todd Hoare,Ram K. Mishra +7 more
TL;DR: If limitations of low aqueous solubility of antipsychotic drugs can be overcome and non-toxic formulations used, IN delivery will gain more importance moving forward given the inherent benefits of IN delivery in comparison to other methods.
49
Patent
Microgel compositions for delivery of substances to the brain
Justin E. Piazza,Todd Hoare,Rodney L. Johnson,Ram K. Mishra,Niels M. B. Smeets,Jayant Bhandari,Ritesh Daya,Yogesh K. Katare,Kevin Skoblenick +8 more
- 29 Aug 2014
TL;DR: In this paper, the authors proposed a microgel composition suitable for delivery of substances to the brain, for example for therapeutic or diagnostic purposes, wherein the substance is entrapped in and/or on the chemically cross-linked microgel.
3
Spectroscopy detects skeletal muscle microvascular dysfunction during onset of sepsis in a rat fecal peritonitis model
Paulina M. Kowalewska,Justin E. Piazza,Stephanie Milkovich,Richard Jove,Lin Wang,Shawn N. Whitehead,Christopher G. Ellis +6 more
TL;DR: In this paper , a rat model of septic peritonitis was used to determine whether early microvascular dysfunction (MVD) in skeletal muscle can be detected as dynamic changes in micro-vascular hemoglobin (MVHb) levels using spectroscopy and whether MVD precedes organ histopathology.
A Novel Intranasal Spray Device for the Administration of Nanoparticles to Rodents
Justin E. Piazza,Chao Zhu,P. Ravi Selvaganapathy,Todd Hoare,Saransh B. Jain,Farhat Hossain,Ram K. Mishra +6 more
TL;DR: A novel pneumatically-driven intranasal spray device for the administration of nanoparticles that is capable of administering extremely small quantities of nanoparticle suspension in a fine spray that disperses the nanoparticles uniformly on to the tissue.